Gabriele Zaffagnini
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gzaffagnini.bsky.social
Gabriele Zaffagnini
@gzaffagnini.bsky.social
860 followers 1.7K following 100 posts
Group Leader at CECAD, University of Cologne.
Interested in reproductive aging, protein homeostasis in oocytes, and super-organelles.
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gzaffagnini.bsky.social
It's Sunday again and a new issue of #cebooc is out!
biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41223274/ on the maternal #mitochondria selection

Runner-up: pubmed.ncbi.nlm.nih.gov/41210958/

Thanks @biomednews.bsky.social for preselecting!
November 16, 2025 at 8:27 AM
gzaffagnini.bsky.social
What an egg-cellent Sunday for oocyte papers! This week we have even TWO highlights:

pubmed.ncbi.nlm.nih.gov/41188464/ by T. Kitajima

and pubmed.ncbi.nlm.nih.gov/41184483/ by @binyammogessie.bsky.social

Read the full issue here: biomed.news/bims-cebooc/...

#cebooc
@biomednews.bsky.social
November 9, 2025 at 9:24 AM
gzaffagnini.bsky.social
Happy Sunday egg-ficionados! Here comes a new issue of #cebooc!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41173887/ on the role of mechanical forces in ovarian follicles development.

As always, thanks to @biomednews.bsky.social for preselecting!
November 2, 2025 at 8:41 AM
gzaffagnini.bsky.social
Happy Sunday ovo-lovers! A new issue of #cebooc is here!

biomed.news/bims-cebooc/...

This week 2 stunning highlights: pubmed.ncbi.nlm.nih.gov/41129643/ and pubmed.ncbi.nlm.nih.gov/41131150/

Thanks @biomednews.bsky.social for preselecting!
October 26, 2025 at 8:04 AM
gzaffagnini.bsky.social
Happy Sunday egg-ficionados! The latest issue of #Cebooc is here!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41102564/

Thanks @biomednews.bsky.social for preselecting!
October 19, 2025 at 8:23 AM
gzaffagnini.bsky.social
Happy Sunday!! Ready for a new spectacular issue of #cebooc?👇🏽

biomed.news/bims-cebooc/...

Highlight: PMID 41066539 on the comparison between human and mouse ovarian aging

Special mention to PMID 41066576 by @frisophagy.bsky.social on mitochondrial selection by mitophagy in the early embryo
October 12, 2025 at 6:41 AM
gzaffagnini.bsky.social
Happy Sunday egg-ficionados! Here come the latest papers on #oocyte cell biology:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/41027914/

Thanks @biomednews.bsky.social for preselecting! #cebooc
October 5, 2025 at 8:08 AM
gzaffagnini.bsky.social
Happy Autumn! Here comes a very rich issue of #cebooc, read all the latest #papers on oocyte cell #biology here:

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40993317/

Kudos to @biomednews.bsky.social for preselecting!
September 28, 2025 at 7:40 AM
gzaffagnini.bsky.social
It was great to attend and give a talk at the Groningen-Jena Aging Meeting (G-JAM)! Very nice conference in a great historical location! Thanks a lot to the organisers @mariaermolaeva.bsky.social and Alessandro Cellerino for the invitation! @leibnizfli.bsky.social @uni-jena.de
September 26, 2025 at 11:02 AM
gzaffagnini.bsky.social
Happy Sunday! Ready for the latest papers on #oocyte cell biology?

Here they come! biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40973727/ by @abalboula.bsky.social and @ejsm9.bsky.social

Thanks @biomednews.bsky.social for preselecting!
September 21, 2025 at 7:25 AM
gzaffagnini.bsky.social
Happy Sunday! Here is a new issue of #cebooc, featuring the latest papers on #oocyte cell biology, enjoy!

biomed.news/bims-cebooc/...

Thanks to @biomednews.bsky.social for preselecting!
September 14, 2025 at 9:28 AM
gzaffagnini.bsky.social
Happy Monday eggficionados, #cebooc is back! Ready for a new year of exciting papers on oocyte cell biology? Start now! 👇🏽

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40902605/

Thanks @biomednews.bsky.social for preselecting
September 8, 2025 at 6:52 AM
gzaffagnini.bsky.social
Here we go again! Our paper on #proteostasis in human oocytes appeared on the latest @embojournal.org cover! A great collaboration with Dexeus Mujer @bokelab.bsky.social ! 🥂👏🏻💪🏻
August 18, 2025 at 12:35 PM
gzaffagnini.bsky.social
Happy Sunday! Here is today's issue of #cebooc with the latest papers on #oocyte biology!

biomed.news/bims-cebooc/...

Highlight: PMID 40803772 by @idajentoft.bsky.social @schuhlab.bsky.social in @annualreviews.bsky.social

Powered by @biomednews.bsky.social

PS: #cebooc goes on 🏖️, cu in Sept!
August 17, 2025 at 7:06 AM
gzaffagnini.bsky.social
Happy Sunday! Here is another great issue of #cebooc, bringing to you the latest papers on #oocyte cell biology!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40768572/ on how human oocytes don't accumulate mtDNA mutations with age.

powered by @biomednews.bsky.social.
August 10, 2025 at 7:33 AM
gzaffagnini.bsky.social
Happy August egg-ficionados! Enjoy this spectacular issue of #cebooc with a lot of useful methods papers!

biomed.news/bims-cebooc/...

Highlight: Iterative oocyte immunofluorescence by
@adelaljord.bsky.social, super useful! pubmed.ncbi.nlm.nih.gov/40736799/

Powered by
@biomednews.bsky.social
August 3, 2025 at 9:31 AM
gzaffagnini.bsky.social
Happy Sunday! A new issue of #cebooc is here, check it out!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40696105/ on the metabolic regulation of embryogenesis

Thanks @biomednews.bsky.social for preselecting!
July 27, 2025 at 8:19 AM
gzaffagnini.bsky.social
Happy Sunday egg-ficionados! Don't miss today's golden issue of #cebooc, the manually curated list of papers on #oocyte cell biology!

biomed.news/bims-cebooc/...

Highlight: pubmed.ncbi.nlm.nih.gov/40664214/ by @takashiakeralab.bsky.social

Thanks @biomednews.bsky.social for preselecting!
July 20, 2025 at 7:31 AM
gzaffagnini.bsky.social
Overall, our study provides a reference for future research on #aged oocytes and from #infertility #patients. With our previous work, our results further highlight how oocytes from different mammalian species adopt different strategies to regulate #proteostasis during their extended #life.

9/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
And what about protein #aggregates? While mouse oocytes store them in large endolysosomal vesicular asseblies (ELVAs), human oocytes seem to sequester them inside individual enlarged lysosomes (similar to what some quiescent stem cells do).

8/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
In most MIIs, mitochondria also start to surround clusters of ER membranes below the cell cortex. Another super-organelle awaiting to be studied maybe?? 🤩

7/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
We also found that organelles undergo a dramatic redistribution from GVs to MIIs: while #lysosomes undergo exocytosis, as highlighted by the appearance of LAMP1 on the cell surface, #mitochondria spread throughout the cytoplasm

6/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
We then compared GVs and MIIs from the same donors. Unlike in #mouse oocytes, the labelling intensity further decreased in human oocytes from GVs to MIIs, suggesting a general downregulation of organelle activity during oocyte maturation.

5/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
We first compared oocytes with the surrounding somatic cells (cumulus cells, CCs). We found that the intensity of all dyes is lower in oocytes compared to the adjacent CCs, suggesting lower organelle activity in the germline.

4/
July 16, 2025 at 11:36 AM
gzaffagnini.bsky.social
We systematically surveyed changes in organelles' activity and localisation during human oocyte maturation by labelling both immature oocytes (GV) and mature eggs (MIIs) with fluorescent dyes for lysosomal, proteasomal, and mitochondrial activity, and imaging them live.

3/
July 16, 2025 at 11:36 AM