Gupse Özcan
@gupseozcan.bsky.social
Doctor of Medicine ⚕
Doctoral Candidate @Universitätsklinikum Jena and @Leibniz FLI
Scientist with a focus on hematology and transcriptional regulation.
Just trying to survive.
📍Jena, Thüringen 🇩🇪
Doctoral Candidate @Universitätsklinikum Jena and @Leibniz FLI
Scientist with a focus on hematology and transcriptional regulation.
Just trying to survive.
📍Jena, Thüringen 🇩🇪
Many thanks to our colloborators in Poland and co-authors, especially my great supervisors Tino Schenk and Martin Fischer.
August 5, 2025 at 8:20 PM
Many thanks to our colloborators in Poland and co-authors, especially my great supervisors Tino Schenk and Martin Fischer.
In this study, we showed that the CDK4/6 inhibitor palbociclib enhanced differentiation and reduced viability and colony-forming capacity in non-APL AML cells. We also performed gene expression analysis, uncovering mechanisms behind the observed synergistic potential of the combination.
August 5, 2025 at 8:18 PM
In this study, we showed that the CDK4/6 inhibitor palbociclib enhanced differentiation and reduced viability and colony-forming capacity in non-APL AML cells. We also performed gene expression analysis, uncovering mechanisms behind the observed synergistic potential of the combination.
All-trans retinoic acid (ATRA) is the cornerstone of differentiation therapy in acute promyelocytic leukemia (APL), but has yet to show the same success in other AML subtypes. This highlights the need for rational combination strategies to overcome resistance and enhance differentiation.
August 5, 2025 at 8:17 PM
All-trans retinoic acid (ATRA) is the cornerstone of differentiation therapy in acute promyelocytic leukemia (APL), but has yet to show the same success in other AML subtypes. This highlights the need for rational combination strategies to overcome resistance and enhance differentiation.