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Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation | Science Advances www.science.org/doi/10.1126/...
Drosophila and mouse intestinal stem cells are spatiotemporally specified by Notch suppression and Wnt activation
Intestinal stem cells are specified by spatiotemporal teamwork: Notch suppression carves fate while Wnt zones set the stage.
www.science.org
January 26, 2026 at 2:39 PM
A project we have worked on for over a decade (for many reasons). I thought it was a major breakthrough, but it turns out my taste is incredibly niche. Thanks to Development for recognizing its potential.

journals.biologists.com/dev/article-...
Kuzbanian expression levels dictate Notch signaling outcomes via interplay between cis- and trans-Delta
Summary: Kuzbanian expression levels set compartment-specific thresholds for Notch activation in the Drosophila midgut by governing the balance between cis-Delta inhibition and trans-Delta activation.
journals.biologists.com
January 26, 2026 at 5:00 AM