Honored to share our article in the @nejm.org Breast Cancer Update discussing two perspectives on anthracycline use in breast cancer—a long-debated topic that remains highly relevant

Grateful to co-author this work with Prof Martine Piccart

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@dfcibreastonc.bsky.social

GeparDouze presented at #SABCS24:

Atezolizumab + chemo in stage II/III TNBC did not significantly improve EFS (HR 0.8; 95% CI 0.62-1.03; p=0.08), 4-year EFS: 85.2% vs 81.9%.

pCR increased from 57% to 63%.

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Post-hoc TAILORx analysis: In HR+/HER2-, LN- breast cancer w/ RS ≥31, anthracycline (T-AC) improved 5-year DRFI (96% vs 91%, aHR 0.32, p=0.009) and DRFS vs TC. Benefit strongest in tumors >2cm, increasing with RS

Results are alligned w/ other MammaPrint High 2 results

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Great presentation on the Association Between Risk-Reducing Surgeries and Survival in Young BRCA Carriers with Breast Cancer by Matteo Lambertini at #SABCS24

Data from >5000 patients show risk-reducing mastectomy and RRSO both improve OS, DFS, and BCFI

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Amazing discussion by @thomasgrinda.bsky.social
at the Poster Spotlight Session 3 - Highlights on novel therapeutics at #SABCS24 putting into context novel immunotherapy, anti-VEGF and chemotherapy combinations and new HER2-targeted ADC

Happy to present at #SABCS24 the results of 4 studies exploring:

- Prognostic/predictive biomarkers of CDK4/6i beyond progression in the PACE trial

- The influence of pregnancy status on the distribution and prognostic value of Oncotype DX in young women

Join us!

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Biomarker analyses of KN-522 shows most markers (T-cell GEP, HRD, HER2 signaling, PTEN, TNBC subtype) were prognostic but not predictive

High TMB showed a signal for pembro benefit, but only in 8% of pts

Predictive biomarkers for ICI in early TNBC are urgently needed!

@oncoalert.bsky.social

MARGOT trial results presented by Dr Ada Waks at #SABCS2024

No statistically sig pCR benefit (56% vs 46%, p=0.25) between preop margetuximab vs. trastuzumab in combination with paclitaxel-pertuzumab in pts with HER2+ BC and CD16 genotype FF or FV

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@dfcibreastonc.bsky.social

RWE is becoming increasingly vital in cancer research

To improve quality, we need to understand where we stand

Happy to share this major effort analyzing 1251 studies mapping RWE

Standardization & ⬆️ collaboration will be 🔑 to increase the relevance of RWD

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