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The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells
Lauriola, Enriqué Steinberg, et al. report that RNF32, a ubiquitin ligase enriched in intestinal stem cells, links calcium levels to NF-κB signaling by activating the IKK complex. This study uncovers a calcium-dependent mechanism involved in responses to bacterial stimuli, revealing how intestinal cells integrate signaling cues to regulate intestinal homeostasis.
dlvr.it
November 21, 2025 at 11:57 PM
The E3 ligase RNF32 controls the IκB kinase complex and NF-κB signaling in intestinal stem cells