New review in JCO Precision Oncology by the NEWTS group of the @euroewing.bsky.social consortium:

Recurrent and Refractory Ewing #Sarcoma Phase I/II Trials: Current Perspective From the Euro-Ewing Consortium

ascopubs.org/doi/10.1200/...

International collaboration is KEY for clinical trials!

Very proud on our stellar doctoral student, Maxim Kafka, for being awarded with a Mildred-Scheel doctoral scholarship from the German Cancer Aid.

Maxim is working @dkfz.bsky.social on a follow-up on our recent paper on #SMARCB1-deficient Epitheloid #Sarcoma

onlinelibrary.wiley.com/doi/10.1002/...

Functionally, AHR silencing restores NK cell-mediated tumor recognition, while also directly suppressing EwS cell proliferation, clonogenicity, and spheroid growth in plasma-like media. Genetic inhibition of AHR reduces tumor burden and metastatic competence in xenograft models.

6/n

Low EWSR1::ETS states foster tryptophan catabolism and accumulation of the AHR agonist kynurenine, which in turn promotes an immunosuppressive tumor microenvironment characterized by impaired natural killer (NK) cell cytotoxicity and enrichment of immunoregulatory infiltrates.

5/n

Check out our updated preprint!

Using functional #metabolomics, we link reduced EWSR1::ETS activity in Ewing #sarcoma to poor outcome and activation of the AHR pathway, which promotes immune evasion characterized by impaired NK cell function and immunoregulatory infiltrates.

tinyurl.com/2b6cry3m

Very proud on our stellar Alina Ritter for her frist first-author paper:

Targeting CXADR-mediated AKT signaling suppresses tumorigenesis and enhances #chemotherapy efficacy in #Ewing #sarcoma

tinyurl.com/3kcs3bc9

@dkfz.bsky.social
@uniheidelberg.bsky.social
@nct-heidelberg.bsky.social

Martha from our lab presents her work on how EWSR1::ETS-low cells reprogram tumor metabolism to suppress NK cell activity at the #EuSARC conference in Venice

www.biorxiv.org/content/10.1...

Very proud on our team for winning the Gold Medal of the LEAF program for improving sustainability practices

So proud on our stellar medical student Florian H. Geyer for his first first-authorship paper!

Comprehensive #DSRCT multi-omics analyses unveil CACNA2D2 as a diagnostic hallmark and super-enhancer-driven EWSR1::WT1 signature gene
tinyurl.com/42fxmmud

@dkfz.bsky.social
@uniheidelberg.bsky.social

🔥Check out our new article on..

Loss of #SMARCB1 evokes targetable epigenetic vulnerabilities in #epithelioid #sarcoma

onlinelibrary.wiley.com/doi/10.1002/...

@dkfz.bsky.social @KiTZ_HD @nct-heidelberg.bsky.social @uniheidelberg.bsky.social