A.LU
@grumpyparticle.bsky.social
Hiking/IC/RPE/QNFT-software. [Based somewhere in Switzerland.]
Follows don't reflect beliefs/principles.
Follows don't reflect beliefs/principles.
(This is super hard to read, I'm still learning how to plot this stuff.)
June 1, 2025 at 12:12 PM
(This is super hard to read, I'm still learning how to plot this stuff.)
Sorry, it took me a long time to get back to this. I've tried to plot all the pathogens in Sentinella here, but I still don't think I understand much more than before (Rhinovirus often correlates with SC2, hmm). I've tried to indicate hotter periods too:
June 1, 2025 at 12:12 PM
Sorry, it took me a long time to get back to this. I've tried to plot all the pathogens in Sentinella here, but I still don't think I understand much more than before (Rhinovirus often correlates with SC2, hmm). I've tried to indicate hotter periods too:
List of mutations is from www.who.int/activities/t... (plus elsewhere for KP.2). As always, reader beware, I have no qualifications in this area.
Tracking SARS-CoV-2 variants
It remains critical that global systems to detect signals of potential variants of interest (VOIs) or variants of concern (VOCs) and rapidly assess the risk posed by SARS-CoV-2 variants to public…
www.who.int
May 21, 2025 at 6:00 PM
List of mutations is from www.who.int/activities/t... (plus elsewhere for KP.2). As always, reader beware, I have no qualifications in this area.
And the FDA is considering LP.8.1 - perhaps we'll know more tomorrow: www.reuters.com/business/hea...
www.medpagetoday.com
May 21, 2025 at 6:00 PM
And the FDA is considering LP.8.1 - perhaps we'll know more tomorrow: www.reuters.com/business/hea...
Meanwhile, the WHO is being a bit wishy washy - LP.8.1 is "a suitable alternative vaccine antigen" whereas JN.1 and KP.2 "remain appropriate": www.who.int/news/item/15...
Statement on the antigen composition of COVID-19 vaccines
The TAG-CO-VAC reconvened on 6-7 May 2025 to review the genetic and antigenic evolution of SARS-CoV-2; immune responses to SARS-CoV-2 infection and/or COVID-19 vaccination; the performance of…
www.who.int
May 21, 2025 at 6:00 PM
Meanwhile, the WHO is being a bit wishy washy - LP.8.1 is "a suitable alternative vaccine antigen" whereas JN.1 and KP.2 "remain appropriate": www.who.int/news/item/15...
The EMA's ETF is recommending LP.8.1 for this year's boosters: www.ema.europa.eu/en/news/etf-...
ETF recommends updating COVID-19 vaccines to target new LP.8.1 variant | European Medicines Agency (EMA)
Updated vaccines will help maintain protection against disease as virus continues to evolve
www.ema.europa.eu
May 21, 2025 at 6:00 PM
The EMA's ETF is recommending LP.8.1 for this year's boosters: www.ema.europa.eu/en/news/etf-...
Nur ein ganz kleiner Kommentar - das mit den monoklonalen Antikörpern stimmt - zumindest in Europa - leider nicht.
Die EMA hat z.B. Kavigale als obsolet bezeichnet, bevor es überhaupt zugelassen wurde. Pemgarda gibt es nur in den USA.
Die EMA hat z.B. Kavigale als obsolet bezeichnet, bevor es überhaupt zugelassen wurde. Pemgarda gibt es nur in den USA.
May 9, 2025 at 3:07 PM
Nur ein ganz kleiner Kommentar - das mit den monoklonalen Antikörpern stimmt - zumindest in Europa - leider nicht.
Die EMA hat z.B. Kavigale als obsolet bezeichnet, bevor es überhaupt zugelassen wurde. Pemgarda gibt es nur in den USA.
Die EMA hat z.B. Kavigale als obsolet bezeichnet, bevor es überhaupt zugelassen wurde. Pemgarda gibt es nur in den USA.
That's an unlikely explanation - they're just going after workplace safety in general. N95s are well established outside of the medical sphere, these reviews (even when badly done) are irrelevant for industrial usage (decades of evidence exist).
May 3, 2025 at 3:10 AM
That's an unlikely explanation - they're just going after workplace safety in general. N95s are well established outside of the medical sphere, these reviews (even when badly done) are irrelevant for industrial usage (decades of evidence exist).
But... is FF possibly an overestimate because it's an average over inbreath and outbreath? (Equally, leakage might still be significant even at peak FF, perhaps I can verify with an N95 companion?)
April 11, 2025 at 4:11 PM
But... is FF possibly an overestimate because it's an average over inbreath and outbreath? (Equally, leakage might still be significant even at peak FF, perhaps I can verify with an N95 companion?)
IME HMFF is almost always significantly lower than peak FF (exceptions apply) -> ergo, leakage must dominate.
There may be better ways to measure filtration efficiency (for local air), but how to ensure that flow rates match what they'd be on my face?
There may be better ways to measure filtration efficiency (for local air), but how to ensure that flow rates match what they'd be on my face?
April 11, 2025 at 4:11 PM
IME HMFF is almost always significantly lower than peak FF (exceptions apply) -> ergo, leakage must dominate.
There may be better ways to measure filtration efficiency (for local air), but how to ensure that flow rates match what they'd be on my face?
There may be better ways to measure filtration efficiency (for local air), but how to ensure that flow rates match what they'd be on my face?
I was wondering if it might just be more tests -> more positives, but I don't think so - positivity seems high:
Alternatively: more severe variant (BA.2.86?) -> more hospitalisations -> more + tests in hospital?
Alternatively: more severe variant (BA.2.86?) -> more hospitalisations -> more + tests in hospital?
April 5, 2025 at 6:24 AM
I was wondering if it might just be more tests -> more positives, but I don't think so - positivity seems high:
Alternatively: more severe variant (BA.2.86?) -> more hospitalisations -> more + tests in hospital?
Alternatively: more severe variant (BA.2.86?) -> more hospitalisations -> more + tests in hospital?
Mittlerweile sind mehrere Impfstoffe in der EU zugelassen, die nicht vom US-Markt abhängen (Kostaive, Bimervax) - ist es also wirklich so schlimm?
(K.A. ob die wirklich liefern können bzw. ob schnelle updates möglich sind.)
(K.A. ob die wirklich liefern können bzw. ob schnelle updates möglich sind.)
April 3, 2025 at 5:41 AM
Mittlerweile sind mehrere Impfstoffe in der EU zugelassen, die nicht vom US-Markt abhängen (Kostaive, Bimervax) - ist es also wirklich so schlimm?
(K.A. ob die wirklich liefern können bzw. ob schnelle updates möglich sind.)
(K.A. ob die wirklich liefern können bzw. ob schnelle updates möglich sind.)
Also curious - not many (European) countries seem to do it, France is the only place I've found so far that recommends it.
March 22, 2025 at 1:04 PM
Also curious - not many (European) countries seem to do it, France is the only place I've found so far that recommends it.
10/53: Jänzi
Quite a spectacular morning.
Quite a spectacular morning.
March 22, 2025 at 11:04 AM
10/53: Jänzi
Quite a spectacular morning.
Quite a spectacular morning.
Mittlerweile ist Terminbuchung wieder Online möglich (seit Ende Februar gab es eine Zeitlang keine Termine mehr).
P.s. vielen Dank für alle diese Infos!
P.s. vielen Dank für alle diese Infos!
March 21, 2025 at 4:52 PM
Mittlerweile ist Terminbuchung wieder Online möglich (seit Ende Februar gab es eine Zeitlang keine Termine mehr).
P.s. vielen Dank für alle diese Infos!
P.s. vielen Dank für alle diese Infos!
9/53: a dreich day up at Alp Unterbüelen. I was led to believe that there's a view up here 🧐.
March 15, 2025 at 6:38 PM
9/53: a dreich day up at Alp Unterbüelen. I was led to believe that there's a view up here 🧐.
8/53: spring has finally arrived
March 9, 2025 at 2:44 PM
8/53: spring has finally arrived
WPF studies do in fact show that N95s can reach 1000x (99.9%) exposure reduction for a very limited number people. This proves that N95s are filtering at far above 95% in realistic circumstances.
(94/95% do remain relevant in the context of the certification tests.)
(94/95% do remain relevant in the context of the certification tests.)
March 2, 2025 at 1:58 PM
WPF studies do in fact show that N95s can reach 1000x (99.9%) exposure reduction for a very limited number people. This proves that N95s are filtering at far above 95% in realistic circumstances.
(94/95% do remain relevant in the context of the certification tests.)
(94/95% do remain relevant in the context of the certification tests.)
There's a common misconception that N95s/FFP2s filter at 95%/94% efficiency. No - real filtration is much higher - these numbers refer to very specific circumstances irrelevant in reality.
There's no need to believe me - here's what OSHA (and L. Brosseau) have to say about it:
There's no need to believe me - here's what OSHA (and L. Brosseau) have to say about it:
![OSHA requested comment in question 7 of the proposal on whether it should limit full facepiece negative pressure respirators to an APF of 20 when N95 filters are used. The NIOSH certification tests for 42 CFR part 84 filters are conducted using monodisperse aerosols of the most penetrating particle size (0.3 [mu]m) delivered at a high flow rate of 85 liters per minute. Also, the 42 CFR part 84 certification standards allow up to 5% filter leakage with an N95 filter. If this level of leakage were to occur in the workplace, an APF of 20 would be appropriate for a full facepiece respirator using N95 filters. However, as several commenters noted (Exs. 9-16, 9-22, 9-23, 9-37, 10-6, 10-17, 10-27, 10-59, and 10-60), workplace filter penetration is always much less than filter penetration estimated from certification testing.](https://cdn.bsky.app/img/feed_thumbnail/plain/did:plc:5mujskdgwddiijdyhtmvadci/bafkreig34o4pwdzax2xddgnc4wcymcuwauaz3qxjn5wlrxsjxr55sny3nu@jpeg)
March 2, 2025 at 1:57 PM
There's a common misconception that N95s/FFP2s filter at 95%/94% efficiency. No - real filtration is much higher - these numbers refer to very specific circumstances irrelevant in reality.
There's no need to believe me - here's what OSHA (and L. Brosseau) have to say about it:
There's no need to believe me - here's what OSHA (and L. Brosseau) have to say about it:
If you want to understand why the UK considers FFP3 to be superior, see bsky.app/profile/grum... (TL;DR: theoretical considerations).
This stuff matters because FFP3s are more expensive and less breathable (the latter factor could **theoretically** lead to more leakage).
This stuff matters because FFP3s are more expensive and less breathable (the latter factor could **theoretically** lead to more leakage).
A.LU (@grumpyparticle.bsky.social)
I think I've finally figured out why the UK insists on FFP3s in healthcare, despite real-life data suggesting that there may be little advantage vs FFP2 **when fit testing has been performed**…
bsky.app
March 2, 2025 at 11:31 AM
If you want to understand why the UK considers FFP3 to be superior, see bsky.app/profile/grum... (TL;DR: theoretical considerations).
This stuff matters because FFP3s are more expensive and less breathable (the latter factor could **theoretically** lead to more leakage).
This stuff matters because FFP3s are more expensive and less breathable (the latter factor could **theoretically** lead to more leakage).