Robert Grosse @ grosselab
@grosselab.bsky.social
all things cytoskeleton - nuclear actin dynamics and genome - nucleoskeleton and nuclear organisation - cancer cell invasion and pharmacology
@University of Freiburg
https://www.pharmakologie.uni-freiburg.de/en/i/research/grosse
@University of Freiburg
https://www.pharmakologie.uni-freiburg.de/en/i/research/grosse
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social
September 22, 2025 at 11:00 AM
we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social
from our 'older' paper Baarlink et al. 2017, live imaging of a dividing mouse fibroblast stably expressing a shuttling chromobody detecting actin - showing nuclear actin filaments during postmitotic nuclear expansion and chromatin decompaction as well as simultaneous membrane dynamics
June 27, 2025 at 11:07 AM
from our 'older' paper Baarlink et al. 2017, live imaging of a dividing mouse fibroblast stably expressing a shuttling chromobody detecting actin - showing nuclear actin filaments during postmitotic nuclear expansion and chromatin decompaction as well as simultaneous membrane dynamics
won't get tired of looking at these...in case you missed it...nuclear actin assemblies with DAAM2 at ligand-stimulated androgen receptors (biomolecular condensates?)
www.nature.com/articles/s41...
we keep working to figure out all the details
www.nature.com/articles/s41...
we keep working to figure out all the details
December 21, 2024 at 10:20 AM
won't get tired of looking at these...in case you missed it...nuclear actin assemblies with DAAM2 at ligand-stimulated androgen receptors (biomolecular condensates?)
www.nature.com/articles/s41...
we keep working to figure out all the details
www.nature.com/articles/s41...
we keep working to figure out all the details