Alterations in the gut microbiome impact immune processes associated with the pathogenesis of multiple sclerosis (MS) and the regulation of metabolic pathways. Probiotics are thought to contribute to

Regenerative strategies in progressive multiple sclerosis pose a significant unmet need. Remyelinating treatments with proremyelinating properties are most promising for future use in combination trea

ROCK inhibition with Y27632 significantly enhanced axonal regeneration, growth cone expansion, retrograde transport, and reinnervation of acetylcholine receptors and Merkel cells after a dorsal root g

Multiple sclerosis (MS) is a progressive neurodegenerative disorder. This study aimed to investigate the effects of Coenzyme Q10 on histomorphometric changes, motor behaviors, and the expression of BD

Poliumoside (POL) is an anti-inflammatory, antioxidant, and neuroprotective molecule. Spinal cord injury (SCI) is a debilitating neurological disorder. Systemic drug toxicity for two POL dosages (15 m

Glucagon-like peptide-1 receptor agonists (GLP-1RAs) were developed for type 2 diabetes and later approved for chronic weight management. They have been shown to reduce oxidative stress, preserve axon

Degeneration of myelinating oligodendrocytes and the resulting breakdown of the myelin sheath are key drivers of neurodegeneration and disability across numerous central nervous system pathologies. Thus, a compelling strategy to preserve neuronal function is to promote endogenous myelin repair by oligodendrocyte precursor cells (OPCs). Extracellular vesicles (EVs) secreted by pro-regenerative microglia have been shown to enhance OPC maturation and remyelination across different experimental m...

Multiple sclerosis (MS) is an autoimmune neuroinflammatory demyelinating disease of the central nervous system that affects more than 2.5 million people worldwide. Remyelination is a regenerative resp

Neogenin, a key molecule for T-cell activation, was used as a targeted molecular gene therapy for MS. Neogenin gene expression was reduced by LNPsiNeo in mouse EL-4 cells and splenocytes of EAE mouse.

Dimethyl fumarate (DMF) is an oral therapy approved for the treatment of relapsing-remitting multiple sclerosis. It is also known to reduce disease severity in experimental autoimmune encephalomyeliti