Finally, thank you PTEN Research Foundation, for supporting our work

GrauperaLab
@MarionaGraupera
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2min
This is a team effort with many involved, but I would especially thank @sandradcastillo.bsky.social the driving force of this work, and Eulàlia Baselga the clinician managing these patients

By demonstrating that the differentiation state and the fate of endothelial cells dictate the cellular response to PIK3CA mutations, we provide a novel paradigm for understanding the mechanisms dictating tissue-specific overgrowth in PIK3CA-related congenital disorders

Our findings expose the (i) generation of large clones in veins and capillaries causing vascular malformations, (ii) silent presence in arterial cells without pathological manifestations; and (iii) rewire of cell fate in arterial precursors