Gary Anderson
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grandsong.bsky.social
Gary Anderson
@grandsong.bsky.social
90 followers 240 following 6 posts
Formerly in healthcare - Long Covidian now
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Reposted by Gary Anderson
mayalongcovid.bsky.social
#PedroPascalPapers
#LongCovidAwarenessDay
@crunchme.bsky.social
Pedro Pascal matched to ME/LongCovid research infographic The future is a policy choice: Addressing Infection-Associated Chronic Conditions Crunch ME, 2025 Medicine has long had a blind spot on Infection-Associated Chronic Conditions (IACC), which include: Long Covid, ME/CFS, POTS, MCAS, Fibromyalgia, & Chronic Lyme Disease. ME/CFS has a greater disease burden than MS & Parkinson's combined, while Long Covid disease burden is comparable to diabetes. Despite the high severity and disease burden, Long Covid & ME/CFS are deeply underfunded in proportion to their Disability-Adjusted Life Years (DALY).
March 16, 2025 at 6:59 PM
Reposted by Gary Anderson
mayalongcovid.bsky.social
#PedroPascalPapers
Pedro Pascal as Neurological Manifestations of #LongCovid #LongCovidAwarenessDay
Pedro Pascal matched to ME/LongCovid research infographic Long Covid Now Looks Like a Neurological Disease Scientific American, 2023 Covid protein found in neurons & astrocytes up to 3 months after initial infection in those with neuropsychiatric symptoms. Autopsies have found Covid RNA in the brain up to 8 months after infection. Those with cognitive problems have immune-related abnormalities in their cerebrospinal fluid & higher amounts of immune cells in the brain that should not be there, causing inflammation. "(Long Covid) is not a psychological or psychosomatic disorder; this is a neuroimmune disorder" Pedro Pascal matched to ME/LongCovid research infographic Current update on the neurological manifestations of long COVID PubMedID: 39850323, 2024 Neuroinflammation: elevated levels of pro-inflammatory cytokines & autoantibodies →chronic inflammation in central & peripheral nervous systems. Latent virus reactivation exacerbates & viral reservoirs may perpetuate inflammation. Endothelial dysfunction damages blood brain barrier. Hypometabolism likely due to mitochondrial dysfunction & oxidative stress are found in high ACE2 areas such as brainstem, hippocampus, olfactory bulb. Autonomic dysfunction is possibly due to damage to the brainstem & vagus nerve. Genetic susceptibility Pedro Pascal matched to ME/LongCovid research infographic Persistence of spike protein at the skull-meninges-brain axis may contribute to the neurological sequelae of COVID-19 Cell, 2024 The accumulation of SARS-CoV-2 spike protein in the skull-meninges-brain axis of human COVID-19 patients was observed, persisting long after viral clearance. Biomarkers of neurodegeneration were elevated in the cerebrospinal fluid from long COVID patients. Proteomic analysis of human skull, meninges, and brain samples revealed dysregulated inflammatory pathways and neurodegeneration-associated changes. Pedro Pascal matched to ME/LongCovid research infographic Microglia dysfunction, neurovascular inflammation & focal neuropathologies are linked to... systemic inflammation in COVID Nature Neuroscience, 2025 Microglial dysfunction, mitochondrial failure & cell death occurs at sites of Covid-associated vascular inflammation. These pathologies are found in several areas of the brain, but more severe in the medulla, where key autonomic centers are localized. Covid induced inflammation may lead to gliovascular failure in the brain, which could be a common contributor to COVID-19-related neuropathologies
March 16, 2025 at 6:59 PM
grandsong.bsky.social
Hi Sabrina! I would appreciate being added to this ME & LC community. Ty. 🙂
November 27, 2024 at 11:31 PM
grandsong.bsky.social
Thank you, Katharina! I'm relieved and comforted seeing you here on Blue Sky. Hopefully, more our Berlin peeps will be here soon. 🫶
November 27, 2024 at 11:10 PM
grandsong.bsky.social
Well, AI DOES seem like it's developing into a silicon-based organic AI lifeform! 😁
November 27, 2024 at 11:06 PM