gracie quirk
@gquirk96.bsky.social
postdoc at emory university🧬 studying pandemics in the lakdawala lab || university of wisconsin genetics & genomics and soccer alum
Reposted by gracie quirk
Shareable link: rdcu.be/en2Dd
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections
Nature Immunology - Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2...
rdcu.be
May 27, 2025 at 8:14 PM
Shareable link: rdcu.be/en2Dd
Reposted by gracie quirk
Always love posts from @enirenberg.bsky.social--this is our hot off the press work with @gquirk96.bsky.social, but he does a better job explaining it than I would!
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
I've been yelling for a while about how imprinting is not the problem with our immune responses to Omicron, and the issue is much more about the intrinsic immunogenicity of Omicron's spike protein (which is poor). This freshly published study provides pretty definitive proof of that 🧵
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections - Nature Immunology
Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron B...
www.nature.com
May 27, 2025 at 6:17 PM
Always love posts from @enirenberg.bsky.social--this is our hot off the press work with @gquirk96.bsky.social, but he does a better job explaining it than I would!
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
TL;DR, as SARS-CoV2 Spike epitopes drifted, many became poorly immunogenic, irrespective of antigenic imprinting/prior immunity.
Reposted by gracie quirk
I've been yelling for a while about how imprinting is not the problem with our immune responses to Omicron, and the issue is much more about the intrinsic immunogenicity of Omicron's spike protein (which is poor). This freshly published study provides pretty definitive proof of that 🧵
Intrinsic immunogenicity is a major determinant of type-specific responses in SARS-CoV-2 infections - Nature Immunology
Bhattacharya and colleagues assess the impact of antigenic imprinting using samples from mRNA vaccinated or unvaccinated individuals primarily infected with the SARS-CoV-2 variants Delta and Omicron B...
www.nature.com
May 27, 2025 at 3:39 PM
I've been yelling for a while about how imprinting is not the problem with our immune responses to Omicron, and the issue is much more about the intrinsic immunogenicity of Omicron's spike protein (which is poor). This freshly published study provides pretty definitive proof of that 🧵
Reposted by gracie quirk
We identified protein domains in LUCA (Last Universal Common Ancestor). Their distinctive amino acid usage reveals the order amino acids were added to the genetic code, based mostly on size. Older proteins hint at earlier alternative codes. 1/15 @seekingluca.bsky.social www.pnas.org/doi/10.1073/...
Order of amino acid recruitment into the genetic code resolved by last universal common ancestor’s protein domains | PNAS
The current “consensus” order in which amino acids were added to the genetic code
is based on potentially biased criteria, such as the absence of s...
www.pnas.org
December 12, 2024 at 3:43 PM
We identified protein domains in LUCA (Last Universal Common Ancestor). Their distinctive amino acid usage reveals the order amino acids were added to the genetic code, based mostly on size. Older proteins hint at earlier alternative codes. 1/15 @seekingluca.bsky.social www.pnas.org/doi/10.1073/...