Evan Gordon
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gordonneuro.bsky.social
Evan Gordon
@gordonneuro.bsky.social
Assistant Professor of Radiology at Washington University in St. Louis. Neuroscientist studying human brain organization with fMRI, functional connectivity, and DTI.
https://sites.wustl.edu/evangordon/
Great question--the answer is yes! We have this data in the Supplement. In the Midnight Scan Club dataset, motor and cognitive tasks with many trials per participant elicited preferential activation in the individual-specific Action and Decision subnetworks.
July 11, 2025 at 2:38 PM
Because later BOLD activity is believed to correspond to earlier delta-band activity, this suggests a temporally ordered processing stream running from Salience, to the strongly-coupled AMN-Decision subnetwork, to AMN-Action, to motor regions.
July 10, 2025 at 7:52 PM
The AMN subnetworks exhibited a distinct temporal ordering of activity. BOLD activity was observed earliest in motor and SCAN networks, and in the Action subnetwork. The other subnetworks exhibited later activity, and Salience network activity was latest.
July 10, 2025 at 7:52 PM
AMN subnetworks were differentially connected to other large-scale brain networks. The Decision subnetwork was most strongly connected to Salience, the Feedback subnetwork was connected to DAN, and the Action subnetwork was connected to Somato-Cognitive Action and motor networks.
July 10, 2025 at 7:52 PM
This Pars Marginalis subnetwork was in a “hole” in the Neurosynth representations. Whatever it does, task fMRI does not capture it well. Interestingly, recent stimulation work by Lyu and Parvizi suggests this region represents the bodily self. doi.org/10.1016/j.ne...
July 10, 2025 at 7:52 PM
Meta-analytic term mapping using Neurosynth data suggested distinct functions for the subnetworks. Three subnetworks were associated with functions related to making Decisions, implementing Actions, and processing Feedback. The last subnetwork (in pars marginalis of the cingulate) was less clear.
July 10, 2025 at 7:52 PM
We used Precision Functional Mapping to identify AMN subnetworks in densely scanned individuals. Spatial variability across individuals makes it difficult to identify network substructures in traditional group-averaged data. However, four distinct AMN subnetworks emerged clearly in PFM individuals.
July 10, 2025 at 7:52 PM
The Action Mode Network was originally termed the Cingulo-Opercular Network based on neuroanatomy. But AMN extends beyond cingulate and operculum, including regions in frontal/parietal cortex, putamen, thalamus, & cerebellum.

AMN is functionally and anatomically distinct from the Salience network.
July 10, 2025 at 7:52 PM
We have argued that the brain’s Action Mode Network controls functions required for goal-directed behavior. www.nature.com/articles/s41...

Now, in new work, we show that AMN contains distinct subnetworks for making decisions, implementing actions, and processing feedback. doi.org/10.1073/pnas...
July 10, 2025 at 7:52 PM