Gokul Madhav
@gokulmadhav.bsky.social
PhD student RWTH Aachen University.
BS-MS, IISER Berhampur. 2023.
BS-MS, IISER Berhampur. 2023.
Reposted by Gokul Madhav
Our paper on the counterintuitive effects of activating dopamine "reward" neurons is out now!
Props to all the trainees, especially Fio Lozada-Perdomo and Yuzhen Chen who did most of the work. Yuzhen is applying for PhD programs now and you'd be lucky to get her!
www.cell.com/iscience/ful...
Props to all the trainees, especially Fio Lozada-Perdomo and Yuzhen Chen who did most of the work. Yuzhen is applying for PhD programs now and you'd be lucky to get her!
www.cell.com/iscience/ful...
Dual roles of Drosophila reward-encoding dopamine neurons in regulating innate and learned behaviors
Neuroscience; Behavioral neuroscience
www.cell.com
November 24, 2025 at 5:18 PM
Our paper on the counterintuitive effects of activating dopamine "reward" neurons is out now!
Props to all the trainees, especially Fio Lozada-Perdomo and Yuzhen Chen who did most of the work. Yuzhen is applying for PhD programs now and you'd be lucky to get her!
www.cell.com/iscience/ful...
Props to all the trainees, especially Fio Lozada-Perdomo and Yuzhen Chen who did most of the work. Yuzhen is applying for PhD programs now and you'd be lucky to get her!
www.cell.com/iscience/ful...
Reposted by Gokul Madhav
Textbook neurons are usually spiking. However, there exist plenty of non-spiking neurons whose information transmission is less understood. Shirahata et al. studied Ca-dynamics of non-spiking mechanosensory neurons in crickets that are sensitive to air flow.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Subcellular Information Processing in Mechanosensory Non‐Spiking Interneurons
We measured membrane potential and Ca2+ responses to airflow from different angles in cricket mechanosensory local non-spiking interneurons (LNIs). LNIs exhibited spatially heterogeneous patterns of ...
onlinelibrary.wiley.com
November 29, 2025 at 3:43 PM
Textbook neurons are usually spiking. However, there exist plenty of non-spiking neurons whose information transmission is less understood. Shirahata et al. studied Ca-dynamics of non-spiking mechanosensory neurons in crickets that are sensitive to air flow.
onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com/doi/10.1111/...
Reposted by Gokul Madhav
📣 iBehave Scientific Retreat 2025! 🌟
@unibonn.bsky.social UKBonn @rwth.bsky.social @fz-juelich.de @mpinb.mpg.de @dzne.science
🙏 Thanks to our invited speakers
Lisa Fenk @mpiforbi.bsky.social
@ValentinNagerl @uni-goettingen.de
Klas Kullander @UppsalaUniversity
France Rose @unicologne.bsky.social
@unibonn.bsky.social UKBonn @rwth.bsky.social @fz-juelich.de @mpinb.mpg.de @dzne.science
🙏 Thanks to our invited speakers
Lisa Fenk @mpiforbi.bsky.social
@ValentinNagerl @uni-goettingen.de
Klas Kullander @UppsalaUniversity
France Rose @unicologne.bsky.social
November 28, 2025 at 12:25 PM
📣 iBehave Scientific Retreat 2025! 🌟
@unibonn.bsky.social UKBonn @rwth.bsky.social @fz-juelich.de @mpinb.mpg.de @dzne.science
🙏 Thanks to our invited speakers
Lisa Fenk @mpiforbi.bsky.social
@ValentinNagerl @uni-goettingen.de
Klas Kullander @UppsalaUniversity
France Rose @unicologne.bsky.social
@unibonn.bsky.social UKBonn @rwth.bsky.social @fz-juelich.de @mpinb.mpg.de @dzne.science
🙏 Thanks to our invited speakers
Lisa Fenk @mpiforbi.bsky.social
@ValentinNagerl @uni-goettingen.de
Klas Kullander @UppsalaUniversity
France Rose @unicologne.bsky.social
Reposted by Gokul Madhav
Behavioral devaluation by local resistance to dopamine
#Drosophila
#Drosophila
Behavioral devaluation by local resistance to dopamine
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 21, 2025 at 5:23 AM
Behavioral devaluation by local resistance to dopamine
#Drosophila
#Drosophila
Reposted by Gokul Madhav
Rewiring an olfactory circuit by altering cell-surface combinatorial code
#Drosophila
#Drosophila
Rewiring an olfactory circuit by altering cell-surface combinatorial code
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 20, 2025 at 6:23 AM
Rewiring an olfactory circuit by altering cell-surface combinatorial code
#Drosophila
#Drosophila
Reposted by Gokul Madhav
Repulsions instruct synaptic partner matching in an olfactory circuit
#Drosophila
#Drosophila
Repulsions instruct synaptic partner matching in an olfactory circuit
#Drosophila
PubMed link
pubmed.ncbi.nlm.nih.gov
November 20, 2025 at 6:23 AM
Repulsions instruct synaptic partner matching in an olfactory circuit
#Drosophila
#Drosophila
Reposted by Gokul Madhav
Looking to start your PhD in 2026?
Check out the opportunities available at the LMB here: www2.mrc-lmb.cam.ac.uk/students/int...
Applications now open!
Deadline: 2nd DEC
Check out the opportunities available at the LMB here: www2.mrc-lmb.cam.ac.uk/students/int...
Applications now open!
Deadline: 2nd DEC
October 22, 2025 at 10:48 AM
Looking to start your PhD in 2026?
Check out the opportunities available at the LMB here: www2.mrc-lmb.cam.ac.uk/students/int...
Applications now open!
Deadline: 2nd DEC
Check out the opportunities available at the LMB here: www2.mrc-lmb.cam.ac.uk/students/int...
Applications now open!
Deadline: 2nd DEC
Reposted by Gokul Madhav
There is still “an urgent need for donations from the community,” says Eric Lai, president of the Fly Board.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/community/fl...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/community/fl...
FlyBase secures funding for year, but future still uncertain
The FlyBase team’s fundraising efforts have proven successful in the short term, but restoration of its federal grant remains uncertain.
www.thetransmitter.org
October 21, 2025 at 6:23 PM
There is still “an urgent need for donations from the community,” says Eric Lai, president of the Fly Board.
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/community/fl...
By @callimcflurry.bsky.social
#neuroskyence
www.thetransmitter.org/community/fl...
Reposted by Gokul Madhav
Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...
September 17, 2025 at 3:14 PM
Now out in @nature.com: Our study discovering a neural circuit in Drosophila that predictively inhibits proprioceptor axons during voluntary leg movements, such as walking and grooming. www.nature.com/articles/s41...
Reposted by Gokul Madhav
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
August 3, 2025 at 3:51 AM
With @megyounger.bsky.social's lab, et al., we present the first connectomics work in the disease-vector mosquito Aedes aegypti, revealing how its brain is wired to detect host cues.
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Preprint: doi.org/10.1101/2025...
#Neuroscience #Connectomics #vEM #VectorBiology 🧪
Reposted by Gokul Madhav
Reposted by Gokul Madhav
How to Escape the ‘Always Busy, Never Productive’ Trap by Priyanka Ja
How to Escape the ‘Always Busy, Never Productive’ Trap
The shortcut to working smarter, not harder.
code.likeagirl.io
July 27, 2025 at 5:30 PM
How to Escape the ‘Always Busy, Never Productive’ Trap by Priyanka Ja
Reposted by Gokul Madhav
We are looking for 2 postdocs to join my lab at Sussex University in Brighton, UK (South of London, on the sea). One position is for a molecular/cell biologist, the other, for a neurobiologist/behavioural person. Drosophila experience desirable. Flyer w/more info below. Please repost. Thank you!
July 24, 2025 at 9:26 PM
We are looking for 2 postdocs to join my lab at Sussex University in Brighton, UK (South of London, on the sea). One position is for a molecular/cell biologist, the other, for a neurobiologist/behavioural person. Drosophila experience desirable. Flyer w/more info below. Please repost. Thank you!
Reposted by Gokul Madhav
Selective octopaminergic tuning of mushroom body circuits during memory formation https://www.biorxiv.org/content/10.1101/2025.06.16.659845v1
June 17, 2025 at 3:15 AM
Selective octopaminergic tuning of mushroom body circuits during memory formation https://www.biorxiv.org/content/10.1101/2025.06.16.659845v1
Reposted by Gokul Madhav
Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex https://www.biorxiv.org/content/10.1101/2025.06.03.657692v1
June 4, 2025 at 6:15 AM
Hierarchical diversification of instinctual behavior neurons by lineage, birth order, and sex https://www.biorxiv.org/content/10.1101/2025.06.03.657692v1
Reposted by Gokul Madhav
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...
www.philanthropy.cam.ac.uk/give-to-camb...
Drosophila Genetic Database
The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...
www.philanthropy.cam.ac.uk
June 3, 2025 at 5:20 PM
URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Any lab using @flybase.bsky.social please donate using the link in post below.
This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.
Reposted by Gokul Madhav
We have a new preprint on the roles of dopamine reward neurons in flies. These neurons are well known for causing learned attraction to cues paired with reward, so we thought they might also promote innate reward-related behaviors - but we actually found the opposite! www.biorxiv.org/content/10.1...
Dual roles of Drosophila reward-encoding dopamine neurons in regulating innate and learned behaviors
Dopaminergic neurons (DANs) play a key role in learning the value of cues that predict reward. The fruit fly Drosophila has provided a powerful model to dissect the mechanisms by which reward-encoding...
www.biorxiv.org
May 27, 2025 at 4:16 PM
We have a new preprint on the roles of dopamine reward neurons in flies. These neurons are well known for causing learned attraction to cues paired with reward, so we thought they might also promote innate reward-related behaviors - but we actually found the opposite! www.biorxiv.org/content/10.1...
Reposted by Gokul Madhav
The Ataxin-2 protein is required in Kenyon cells for RNP-granule assembly and appetitive long-term memory formation. https://www.biorxiv.org/content/10.1101/2025.05.15.654326v1
May 16, 2025 at 7:15 AM
The Ataxin-2 protein is required in Kenyon cells for RNP-granule assembly and appetitive long-term memory formation. https://www.biorxiv.org/content/10.1101/2025.05.15.654326v1
Reposted by Gokul Madhav
Bigger is not always better: size-dependent fitness effects of adult crowding in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.04.21.649761v1
April 23, 2025 at 2:31 PM
Bigger is not always better: size-dependent fitness effects of adult crowding in Drosophila melanogaster https://www.biorxiv.org/content/10.1101/2025.04.21.649761v1
Reposted by Gokul Madhav
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
April 10, 2025 at 6:06 AM
If using Bloomigton #Drosophila Stock Center stocks, pls. acknowledge them & their NIH funding (P40 OD018537). Papers listing this no. are being harvested as evidence. We massively depend on the @bdsc.bsky.social & they need our support in these dire times! @flybase.bsky.social @fly-eds.bsky.social
Reposted by Gokul Madhav
I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Connectome-driven neural inventory of a complete visual system - Nature
A connectome of the right optic lobe from a male fruitfly is presented together with an extensive collection of genetic drivers matched to a comprehensive neuron-type catalogue.
www.nature.com
March 27, 2025 at 10:58 PM
I know there's a 𝒍𝒐𝒕 going on right now, but I couldn’t be prouder to share this long-incubated labor of love: the complete connectome of the male 𝐷𝑟𝑜𝑠𝑜𝑝ℎ𝑖𝑙𝑎 optic lobe 🧠🪰
🔗 www.nature.com/articles/s41...
🔗 www.nature.com/articles/s41...
Reposted by Gokul Madhav
Really proud to see my postdoc work out!!
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
Touch-evoked traveling waves establish a translaminar spacetime code
Translaminar spacetime patterns organized by feedback-dependent cortical circuits support sparse traveling waves.
www.science.org
January 31, 2025 at 10:54 PM
Really proud to see my postdoc work out!!
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
We used flexible, semi-transparent NeuroGrids to record traveling waves while simultaneously mapping cellular and subcellular dynamics with two-photon imaging
www.science.org/doi/10.1126/...
Reposted by Gokul Madhav
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's @ivychanchiwai.bsky.social findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Odour representations supporting ethology-relevant categorisation and discrimination in the Drosophila mushroom body
Neural representations of sensory stimuli serve multiple distinct purposes, from the rapid recognition of familiar environments, to the precise identification of individual salient cues. In the insect...
www.biorxiv.org
January 27, 2025 at 2:17 PM
Excited to share our new preprint: How does the fly mushroom body support odour categorisation and discrimination? 🧠✨ Dive into Ivy Chan's @ivychanchiwai.bsky.social findings on how neural circuits enable complex olfactory processing in flies. Check it out here:
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Gokul Madhav
Apparently it’s #FlyDay or #DrosophilaDay in honour of the day Drosophila melanogaster, the common fruit fly or vinegar fly line w1118 (the first variant with the white eyes) was isolated, so enjoy some drosophila #sciart! 🧪 #inverts This print highlights the model organism with a ring of 5 of 🧵1/n
November 18, 2023 at 3:53 PM
Apparently it’s #FlyDay or #DrosophilaDay in honour of the day Drosophila melanogaster, the common fruit fly or vinegar fly line w1118 (the first variant with the white eyes) was isolated, so enjoy some drosophila #sciart! 🧪 #inverts This print highlights the model organism with a ring of 5 of 🧵1/n
Reposted by Gokul Madhav
Transcriptional profiling of Drosophila male-specific P1 (pC1) neurons https://www.biorxiv.org/content/10.1101/2023.11.07.566045v1
Transcriptional profiling of Drosophila male-specific P1 (pC1) neurons https://www.biorxiv.org/content/10.1101/2023.11.07.566045v1
In Drosophila melanogaster, the P1 (pC1) cluster of male-specific neurons both integrates sensory cu
www.biorxiv.org
November 11, 2023 at 5:16 AM
Transcriptional profiling of Drosophila male-specific P1 (pC1) neurons https://www.biorxiv.org/content/10.1101/2023.11.07.566045v1