Cynthia (Cindy) McMillen, PhD
@goingviral88.bsky.social
Bunyavirologist working hard to understand vertical transmission in humans and livestock. Lover of whiskey, dogs, and spending time outdoors. Research Assistant Professor at the Univesity of Pittsburgh, School of Public Health, Center for Vaccine Research
This is the first lab evidence explaining how OROV may pass from mother to fetus. @PittTweet @PittCVR @MageeWomens #lovevirology @PittPublicHealth
Read more: rdcu.be/eukST
#Virology #PregnancyResearch #OropoucheVirus #InfectiousDisease #MaternalHealth
Read more: rdcu.be/eukST
#Virology #PregnancyResearch #OropoucheVirus #InfectiousDisease #MaternalHealth
Oropouche virus infects human trophoblasts and placenta explants
Nature Communications - Using several complementary models, including human iPSC-derived trophoblasts, trophoblast organoids, and placenta explants, the authors find cytotrophoblasts and...
rdcu.be
July 3, 2025 at 5:35 PM
This is the first lab evidence explaining how OROV may pass from mother to fetus. @PittTweet @PittCVR @MageeWomens #lovevirology @PittPublicHealth
Read more: rdcu.be/eukST
#Virology #PregnancyResearch #OropoucheVirus #InfectiousDisease #MaternalHealth
Read more: rdcu.be/eukST
#Virology #PregnancyResearch #OropoucheVirus #InfectiousDisease #MaternalHealth
3) Infection of villous explants may vary with gestational age
July 3, 2025 at 5:35 PM
3) Infection of villous explants may vary with gestational age
Beautiful #fluorescence images from @ChristinaMegli shows #Oropouche virus infection throughout the chorionic villi including #syncytiotrophoblast, a cell that generally protects the placenta from viral infection.
July 3, 2025 at 5:35 PM
Beautiful #fluorescence images from @ChristinaMegli shows #Oropouche virus infection throughout the chorionic villi including #syncytiotrophoblast, a cell that generally protects the placenta from viral infection.
Using trophoblast cultures 🧫, 3D trophoblast #organoids and #placenta explants, we showed: 1) OROV replicates rapidly in cytotrophoblast (CTB) and syncytiotrophoblasts (STB).
July 3, 2025 at 5:35 PM
Using trophoblast cultures 🧫, 3D trophoblast #organoids and #placenta explants, we showed: 1) OROV replicates rapidly in cytotrophoblast (CTB) and syncytiotrophoblasts (STB).
The #emerging OROV virus —previously known for causing flu-like illness—is now linked to miscarriages, stillbirths, & neonatal deaths. Our study reveals the OROV #prototype strain BeAn19991 can infect human #placenta tissue, including #trophoblasts, key cells at the maternal-fetal interface.
July 3, 2025 at 5:35 PM
The #emerging OROV virus —previously known for causing flu-like illness—is now linked to miscarriages, stillbirths, & neonatal deaths. Our study reveals the OROV #prototype strain BeAn19991 can infect human #placenta tissue, including #trophoblasts, key cells at the maternal-fetal interface.
This important collaborative work with the Megli (@ChristinaMegli) and Hartman (@RogueRifter) labs provides valuable insight into the possible mechanisms of #oropouche virus (OROV) vertical transmission.
July 3, 2025 at 5:35 PM
This important collaborative work with the Megli (@ChristinaMegli) and Hartman (@RogueRifter) labs provides valuable insight into the possible mechanisms of #oropouche virus (OROV) vertical transmission.
This important collaborative work with the Megli and Hartman (@roguerifter.bsky.social) labs will provide valuable insight into the possible mechanisms of OROV vertical transmission. @pitt.bsky.social #lovevirology
November 17, 2024 at 10:36 PM
This important collaborative work with the Megli and Hartman (@roguerifter.bsky.social) labs will provide valuable insight into the possible mechanisms of OROV vertical transmission. @pitt.bsky.social #lovevirology
Other tissues, including the amniotic membrane, are also susceptible to #Oropouche infection. Altogether, there is a possible preference for earlier gestational tissues --- more studies of this kind are needed to confirm.
November 17, 2024 at 10:36 PM
Other tissues, including the amniotic membrane, are also susceptible to #Oropouche infection. Altogether, there is a possible preference for earlier gestational tissues --- more studies of this kind are needed to confirm.
Staining patterns in the villous look like what we previously found with the related #bunyavirus #RVFV.
November 17, 2024 at 10:36 PM
Staining patterns in the villous look like what we previously found with the related #bunyavirus #RVFV.
Beautiful #fluorescence images from the Megli Lab show #Oropouche virus infection throughout the chorionic villi including syncytiotrophoblast, a cell that generally protects the placenta from viral infection.
November 17, 2024 at 10:36 PM
Beautiful #fluorescence images from the Megli Lab show #Oropouche virus infection throughout the chorionic villi including syncytiotrophoblast, a cell that generally protects the placenta from viral infection.
Using placenta #explants, we saw chorionic villous cultures are permissive to #Oropouche virus infection.
November 17, 2024 at 10:36 PM
Using placenta #explants, we saw chorionic villous cultures are permissive to #Oropouche virus infection.
#Oropouche virus undergoes robust replication in 3D trophoblast #organoids, important cells that compose the #placenta.
November 17, 2024 at 10:36 PM
#Oropouche virus undergoes robust replication in 3D trophoblast #organoids, important cells that compose the #placenta.