Thanks to the European Innovative Training Network 953327 “Serotonin and Beyond” (@erc.europa.eu) and the Collaborative Research Center 289 “Treatment Expectation” (@sfb-trr-289.bsky.social; @dfg.de) for the support.

bpspubs.onlinelibrary.wiley.com/doi/10.1111/...

Through applying advanced behavioral assessment including 50-kHz ultrasonic vocalizations as a marker for positive affect, @tianhuawang.bsky.social from the @wohrlab.bsky.social demonstrated that arousal and euphoria vastly depend on intact serotonergic neurotransmission. @britpharmsoc.bsky.social

The party drug MDMA (“ecstasy”) shows promising efficacy as adjunct to psychotherapy. The psychostimulant with entactogenic properties is known to induce arousal and euphoria. We now studied the neurochemistry underlying the behavioral effects of MDMA in rats lacking serotonin in the brain.