GLIORESOLVE
@glioresolve.bsky.social
Horizon Europe MSCA Doctoral Network identifying a new tumour microenvironment-targeting platform for brain tumours. Find us at www.glioresolve.eu
5️⃣ Big Picture 🏆
This study beautifully bridges the Nobel-Prize discovery of Tregs with next-gen brain tumor immunotherapy — turning immune brakes into powerful therapeutic levers.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00162-1
This study beautifully bridges the Nobel-Prize discovery of Tregs with next-gen brain tumor immunotherapy — turning immune brakes into powerful therapeutic levers.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00162-1
Regulatory T cell depletion promotes myeloid cell activation and glioblastoma response to anti-PD1 and tumor-targeting antibodies
Glioblastoma is an aggressive subtype of glioma that responds poorly to immune checkpoint
blockade (ICB). Galvez-Cancino et al. demonstrate that Treg cell depletion using a
non-IL-2 blocking antibody—...
cell.com
November 2, 2025 at 7:53 PM
5️⃣ Big Picture 🏆
This study beautifully bridges the Nobel-Prize discovery of Tregs with next-gen brain tumor immunotherapy — turning immune brakes into powerful therapeutic levers.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00162-1
This study beautifully bridges the Nobel-Prize discovery of Tregs with next-gen brain tumor immunotherapy — turning immune brakes into powerful therapeutic levers.
🔗 cell.com/immunity/fulltext/S1074-7613(25)00162-1
4️⃣ Double Advantage ⚡️
These same macrophages amplify the power of tumor-targeting antibodies like anti-EGFRvIII, linking adaptive and innate immunity for stronger tumor control.
These same macrophages amplify the power of tumor-targeting antibodies like anti-EGFRvIII, linking adaptive and innate immunity for stronger tumor control.
November 2, 2025 at 7:53 PM
4️⃣ Double Advantage ⚡️
These same macrophages amplify the power of tumor-targeting antibodies like anti-EGFRvIII, linking adaptive and innate immunity for stronger tumor control.
These same macrophages amplify the power of tumor-targeting antibodies like anti-EGFRvIII, linking adaptive and innate immunity for stronger tumor control.
3️⃣ When Tregs Step Out, Immunity Steps In 💥
Without Tregs, monocyte-derived macrophages take the stage — eliminating Tregs via ADCC/ADCP and helping clear tumor cells in an antibody-dependent way.
Without Tregs, monocyte-derived macrophages take the stage — eliminating Tregs via ADCC/ADCP and helping clear tumor cells in an antibody-dependent way.
November 2, 2025 at 7:53 PM
3️⃣ When Tregs Step Out, Immunity Steps In 💥
Without Tregs, monocyte-derived macrophages take the stage — eliminating Tregs via ADCC/ADCP and helping clear tumor cells in an antibody-dependent way.
Without Tregs, monocyte-derived macrophages take the stage — eliminating Tregs via ADCC/ADCP and helping clear tumor cells in an antibody-dependent way.
2️⃣ The Smart Move 🎯
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
November 2, 2025 at 7:53 PM
2️⃣ The Smart Move 🎯
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Using a non-IL-2-blocking anti-CD25 antibody, they cut off IL-2 — Tregs’ fuel — while freeing it for CD8⁺ T cells. This shift activates phagocytic myeloid cells and boosts immune attack.
Here are some links that may be of use if you or your family members are facing a glioblastoma diagnosis theibta.org
braintumourireland.com
stophersentumoren.nl
brainstrust.org.uk
www.thebraintumourcharity.org
artc-asso.fr www.thebraintumourcharity.org/living-with-...
braintumourireland.com
stophersentumoren.nl
brainstrust.org.uk
www.thebraintumourcharity.org
artc-asso.fr www.thebraintumourcharity.org/living-with-...
IBTA – The International Brain Tumour Alliance (IBTA)
theibta.org
July 16, 2025 at 11:30 AM
Here are some links that may be of use if you or your family members are facing a glioblastoma diagnosis theibta.org
braintumourireland.com
stophersentumoren.nl
brainstrust.org.uk
www.thebraintumourcharity.org
artc-asso.fr www.thebraintumourcharity.org/living-with-...
braintumourireland.com
stophersentumoren.nl
brainstrust.org.uk
www.thebraintumourcharity.org
artc-asso.fr www.thebraintumourcharity.org/living-with-...