Gleason Research Group
@gleason-group.bsky.social
Organic and Medicinal Chemistry at McGill University
Group website: http://gleason-group.mcgill.ca
Group website: http://gleason-group.mcgill.ca
Congrats to Anthony Izzotti on a successful thesis defence. Amazing work on cyclopropane expansions, conformational effects of spirocyclopropane-cyclohexanes and once and for all proving that the [14+2] cycloaddition of heptafulvalene is not a Woodward-Hoffman controlled process.
March 3, 2025 at 4:46 PM
Congrats to Anthony Izzotti on a successful thesis defence. Amazing work on cyclopropane expansions, conformational effects of spirocyclopropane-cyclohexanes and once and for all proving that the [14+2] cycloaddition of heptafulvalene is not a Woodward-Hoffman controlled process.
This looks like a disaster for US University funding.
Uh, this is a nuclear bomb on university budgets if I am reading it correctly. Mandating an indirect cost rate of 15% *overnight*?
February 8, 2025 at 12:07 AM
This looks like a disaster for US University funding.
A nice write-up of our recent work on the axial-promoting effect of cyclopropanes.
www.chemistryworld.com/news/cyclopr...
www.chemistryworld.com/news/cyclopr...
Cyclopropyl effect causes substituents on cyclohexane to favour axial conformation
'Unusual stereocontrol element' will help medicinal chemists increase three-dimensionality of drug candidates
www.chemistryworld.com
November 7, 2024 at 10:58 PM
A nice write-up of our recent work on the axial-promoting effect of cyclopropanes.
www.chemistryworld.com/news/cyclopr...
www.chemistryworld.com/news/cyclopr...
For our first Blue Sky post: Our paper on the surprising effect of cyclopropanes on A-values is now out (in preliminary form) in Chem. Sci. If you want to push a large or electronegative group axial on a ring, just stick a cyclopropane next to it.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...
Driving tert-Butyl Axial: The Surprising Cyclopropyl Effect
The presence of a small spirocyclic ring at an adjacent position alters the conformational preference for equatorial substitution in six-membered rings. DFT calculations and low-temperature 1H NMR exp...
pubs.rsc.org
October 9, 2024 at 1:01 AM
For our first Blue Sky post: Our paper on the surprising effect of cyclopropanes on A-values is now out (in preliminary form) in Chem. Sci. If you want to push a large or electronegative group axial on a ring, just stick a cyclopropane next to it.
pubs.rsc.org/en/content/a...
pubs.rsc.org/en/content/a...