Giulio Ragazzon
@giuliosflask.bsky.social
Here mostly a chemist. Interested in endergonic processes and other cool stuff. Group leader at the University of Strasbourg.
Shoutout to Kaiyuan, Federico, & Shaymaa (not on bsky), as well as a big thank you to our collaborators (@stefanborsley.bsky.social, @epenocchio.bsky.social, @claudiabonfio.bsky.social), and Job's team!
June 5, 2025 at 4:19 PM
Shoutout to Kaiyuan, Federico, & Shaymaa (not on bsky), as well as a big thank you to our collaborators (@stefanborsley.bsky.social, @epenocchio.bsky.social, @claudiabonfio.bsky.social), and Job's team!
I believe these works are also a nice example of how focusing on network properties (and specifically ratchet mechanisms, the principles underlying molecular machines) enables rather complex tasks using very simple molecules.
June 5, 2025 at 4:19 PM
I believe these works are also a nice example of how focusing on network properties (and specifically ratchet mechanisms, the principles underlying molecular machines) enables rather complex tasks using very simple molecules.
A bit that I particularly like of our work: we did the key experiments guided by theory, which helped us to find conditions where small differences were amplified, and even revealed nonlinearities.
June 5, 2025 at 4:19 PM
A bit that I particularly like of our work: we did the key experiments guided by theory, which helped us to find conditions where small differences were amplified, and even revealed nonlinearities.
The two works have the same root, but then explore different aspects: Boekhoven and coworkers realized selective transport, while we focused on kinetic aspects which enable pumping in the presence of a chemical fuel on either side of the barrier.
June 5, 2025 at 4:19 PM
The two works have the same root, but then explore different aspects: Boekhoven and coworkers realized selective transport, while we focused on kinetic aspects which enable pumping in the presence of a chemical fuel on either side of the barrier.
Long story short, the works were treated largely independently: we found constructive editors and reviewers, but the randomness of peer review also appeared. For us it was a bit faster, so we waited to share the work more broadly, ideally returning the big favor they did initially by waiting for us.
June 5, 2025 at 4:19 PM
Long story short, the works were treated largely independently: we found constructive editors and reviewers, but the randomness of peer review also appeared. For us it was a bit faster, so we waited to share the work more broadly, ideally returning the big favor they did initially by waiting for us.
So, we coordinated: they were incredibly kind [thanks!🙌] to wait for us to write the manuscript and few [very intense] weeks later we uploaded to ChemRxiv both works, submitting then to the same peer reviewed journal.
June 5, 2025 at 4:19 PM
So, we coordinated: they were incredibly kind [thanks!🙌] to wait for us to write the manuscript and few [very intense] weeks later we uploaded to ChemRxiv both works, submitting then to the same peer reviewed journal.
They had decided to write the work and had the manuscript basically ready, while we were still attempting transport through lipid membranes.
June 5, 2025 at 4:19 PM
They had decided to write the work and had the manuscript basically ready, while we were still attempting transport through lipid membranes.
Job & his team were incredibly open in discussing their findings. We had both achieved the key milestones, and both teams attempted transport through lipid membranes with little success.
June 5, 2025 at 4:19 PM
Job & his team were incredibly open in discussing their findings. We had both achieved the key milestones, and both teams attempted transport through lipid membranes with little success.
..first thing he mention upon arrival : they were also working on active transport! 😱
June 5, 2025 at 4:19 PM
..first thing he mention upon arrival : they were also working on active transport! 😱
Last fall I was invited by @boekhovenlab.bsky.social at TUM for a PhD defense: we had been using "their" carbodiimides to achieve active transport and was looking forward to discussing the systems with him, so I anticipated the topic shortly before arriving..
June 5, 2025 at 4:19 PM
Last fall I was invited by @boekhovenlab.bsky.social at TUM for a PhD defense: we had been using "their" carbodiimides to achieve active transport and was looking forward to discussing the systems with him, so I anticipated the topic shortly before arriving..