🔎 MA of 17 RCT - 4k patients out now in @bjsopen.bsky.social
🏆 Whipple level 1a: selective early drain removal
🏆 Left panc: no drain policy
🎖️ Do you stick to highest level of evidence?! 🫵
academic.oup.com/bjsopen/arti...
🔎 MA of 17 RCT - 4k patients out now in @bjsopen.bsky.social
🏆 Whipple level 1a: selective early drain removal
🏆 Left panc: no drain policy
🎖️ Do you stick to highest level of evidence?! 🫵
academic.oup.com/bjsopen/arti...
An amazing experience to learn and exchange knowledge on an evolving / crucial issue!
An amazing experience to learn and exchange knowledge on an evolving / crucial issue!
🧑🧑🧒🧒 1k pts / 90 days thrombosis 7% in Annals of Surgery
🔮 Predictors resection type / graft material
🩸 Therapeutic anticoagulation 📉 early thrombosis but 👎 at 90 days
journals.lww.com/annalsofsurg...
🧑🧑🧒🧒 1k pts / 90 days thrombosis 7% in Annals of Surgery
🔮 Predictors resection type / graft material
🩸 Therapeutic anticoagulation 📉 early thrombosis but 👎 at 90 days
journals.lww.com/annalsofsurg...
Neoadjuvant FOLFIRINOX 🤜🤛 Gemcitabine based chemoradiotherapy in resecatble / BR
⚖️ No difference in overall survival
😰 Serious adverse events 40%
👍 Both regimens may be considered
www.thelancet.com/pdfs/journal...
Neoadjuvant FOLFIRINOX 🤜🤛 Gemcitabine based chemoradiotherapy in resecatble / BR
⚖️ No difference in overall survival
😰 Serious adverse events 40%
👍 Both regimens may be considered
www.thelancet.com/pdfs/journal...
Aimed at fostering the new generation of pancreatologists… almost 2 years with 5 in person meetings! #science #passion #education and #pancreas
🫵 Join us! Applications open in October
Aimed at fostering the new generation of pancreatologists… almost 2 years with 5 in person meetings! #science #passion #education and #pancreas
🫵 Join us! Applications open in October
☝️Incidence in <50 y/o rising particularly in 🚺
🧬 Germline mutations but most sporadic
🚬 Modifiable factors smoke/alcohol/diet
🔬 Multidisciplinarity + research needed
academic.oup.com/bjs/article/...
☝️Incidence in <50 y/o rising particularly in 🚺
🧬 Germline mutations but most sporadic
🚬 Modifiable factors smoke/alcohol/diet
🔬 Multidisciplinarity + research needed
academic.oup.com/bjs/article/...
🔬 Optimal pathology assessment 🤝 Multidisciplinary pathways leading to best treatment
🔜 Future research line have been defined in @myueg.bsky.social journal!
onlinelibrary.wiley.com/doi/10.1002/ue…
🔬 Optimal pathology assessment 🤝 Multidisciplinary pathways leading to best treatment
🔜 Future research line have been defined in @myueg.bsky.social journal!
onlinelibrary.wiley.com/doi/10.1002/ue…
♐️ Post LT recurrence liver > F; 🫁 only in M
🔮 Survival predicted by CEA, 👉 sided CRC, tumor size, 🧬 KRAS mutation
🔑 Selection criteria key factor
www.jhep-reports.eu/article/S258...
@jhepatology.bsky.social
♐️ Post LT recurrence liver > F; 🫁 only in M
🔮 Survival predicted by CEA, 👉 sided CRC, tumor size, 🧬 KRAS mutation
🔑 Selection criteria key factor
www.jhep-reports.eu/article/S258...
@jhepatology.bsky.social
Even more tricky in case of comorbidities like liver fibrosis … ⚖️ where do you set your threshold for surgery?! 🧐
Even more tricky in case of comorbidities like liver fibrosis … ⚖️ where do you set your threshold for surgery?! 🧐
💉 Triggered by improvements in non surgical therapies 🧰 Many techniques included
🏆 Able to improve survival!
💡 All u need to know ⬇ comprehensive review in @bjsopen.bsky.social
academic.oup.com/bjsopen/arti...
💉 Triggered by improvements in non surgical therapies 🧰 Many techniques included
🏆 Able to improve survival!
💡 All u need to know ⬇ comprehensive review in @bjsopen.bsky.social
academic.oup.com/bjsopen/arti...
A unique team led by Christoph Michalski paving the way to treat pancreas cancer in a modern fashion, taking into account biology 🧬 and “extreme” surgery 🪡
A unique team led by Christoph Michalski paving the way to treat pancreas cancer in a modern fashion, taking into account biology 🧬 and “extreme” surgery 🪡
POPF 🐳 after distal pancreatectomy still a poorly understood complication 🙃
🌍 International validation of the fistula risk score 800 pts
🧯POPF predicted by BMI, NAT, robot approach 🤔
FRS insufficient discrimination 🧐 !!!
link.springer.com/article/10.1...
POPF 🐳 after distal pancreatectomy still a poorly understood complication 🙃
🌍 International validation of the fistula risk score 800 pts
🧯POPF predicted by BMI, NAT, robot approach 🤔
FRS insufficient discrimination 🧐 !!!
link.springer.com/article/10.1...
👇🎓💪
“Improving outcomes in minimally invasive #pancreatoduodenectomy” incl the #DIPLOMA2 RCT. @abuhilal.bsky.social
⏩️ hdl.handle.net/11245.1/5ba777…
Thank you @gio-marchegiani.bsky.social for being here with excellent discussion!
👇🎓💪
From 🔮 prediction to 🧯prevention of complications in pancreas surgery… a risk based approach to 🐳 POPF assessing POH 🧪 and PPAP!
Thank you for having me, HPB conferences in Japan are simply impossible to beat 🤯
From 🔮 prediction to 🧯prevention of complications in pancreas surgery… a risk based approach to 🐳 POPF assessing POH 🧪 and PPAP!
Thank you for having me, HPB conferences in Japan are simply impossible to beat 🤯
A very slippery 🧽 topic!!!
Indeed 2️⃣ different entities in 1️⃣…
IPMN derived cancer follow distinct 🧬 pathways 🆚 conventional PDAC but are way less explored (NOT a single RCT) 👉 knowledge gap!
A very slippery 🧽 topic!!!
Indeed 2️⃣ different entities in 1️⃣…
IPMN derived cancer follow distinct 🧬 pathways 🆚 conventional PDAC but are way less explored (NOT a single RCT) 👉 knowledge gap!
Thank you @maloehr.bsky.social
United for the pancreas, always!
Thank you @maloehr.bsky.social
United for the pancreas, always!
So excited to serve as a mentor also for the second edition after a previous successful journey
So excited to serve as a mentor also for the second edition after a previous successful journey
🇯🇵 2.5k pts > 5 years surveillance
🫧 IPMN size and growth predict cancer within 5 years
🤏 MPD diameter at 5 years predicts cancer after 5 years
gut.bmj.com/content/74/6...
🇯🇵 2.5k pts > 5 years surveillance
🫧 IPMN size and growth predict cancer within 5 years
🤏 MPD diameter at 5 years predicts cancer after 5 years
gut.bmj.com/content/74/6...
👉 Preop chemo with PAXG 🆚 mFOLFIRINOX for extending event-free survival (EFS) in resectable or BR PDAC (phase 3 CASSANDRA trial)
🆙 PAXG 3-year EFS 31% vs. 13% P = .003
🫸 Immature analysis for survival but.. future practice changing?! 🧐
@ascopost.bsky.social
👉 Preop chemo with PAXG 🆚 mFOLFIRINOX for extending event-free survival (EFS) in resectable or BR PDAC (phase 3 CASSANDRA trial)
🆙 PAXG 3-year EFS 31% vs. 13% P = .003
🫸 Immature analysis for survival but.. future practice changing?! 🧐
@ascopost.bsky.social
🐳 POH predicts POPF
⚡️ PPAP causes POPF, DGE, PPH and mortality
👉 Check amylase early and get ready to mitigate 🧯postop complications!
#HPBSky #SurgSky
www.sciencedirect.com/science/arti...
🐳 POH predicts POPF
⚡️ PPAP causes POPF, DGE, PPH and mortality
👉 Check amylase early and get ready to mitigate 🧯postop complications!
#HPBSky #SurgSky
www.sciencedirect.com/science/arti...
🇯🇵 Analysis of 200 PDAC + artery
👗 Divestment (120 cases) most used in first 5 years
🎖️Last 5 years ⬆️ Neoadjuvant chemo + resection ⬇️ complications 👍
academic.oup.com/bjsopen/arti...
🇯🇵 Analysis of 200 PDAC + artery
👗 Divestment (120 cases) most used in first 5 years
🎖️Last 5 years ⬆️ Neoadjuvant chemo + resection ⬇️ complications 👍
academic.oup.com/bjsopen/arti...
Anatomically resectable 🆚 biologically borderline PDAC
🩻 886 pts with identical imaging appearance
🪡 With upfront surgery 🧪 Biologically BR had worse DSS (54 vs. 27 months)
✌️different entities ✌️different approaches
academic.oup.com/bjsopen/arti...
Anatomically resectable 🆚 biologically borderline PDAC
🩻 886 pts with identical imaging appearance
🪡 With upfront surgery 🧪 Biologically BR had worse DSS (54 vs. 27 months)
✌️different entities ✌️different approaches
academic.oup.com/bjsopen/arti...
💉 171 pts median PFS 9 months better in FOLFIRINOX group
🎯 FOLFIRINOX improves PFS significantly compared with gemcitabine and is well tolerated in LAPC
ascopubs.org/doi/10.1200/...
💉 171 pts median PFS 9 months better in FOLFIRINOX group
🎯 FOLFIRINOX improves PFS significantly compared with gemcitabine and is well tolerated in LAPC
ascopubs.org/doi/10.1200/...