Increased epigenetic age difference mediates a portion of the association of PM2.5 and neighbourhood disadvantage with transplant-free survival in fILD!

PM2.5 and it's constituent components (except for sea salt) are all associated with increased epigenetic age difference in patients with fILD. Maybe living by the ocean keeps you younger 😜

Advanced epigenetic age is assoc with substantially worse survival in fILD. 17% increased risk of death or transplant with each 1-year increase epigenetic age difference (epigenetic age - chronological age)

Thrilled to share our work on #epigeneticaging in fibrotic ILD out today in ERJ! Pts with fILD are a median of 12yrs epigenetically older than their biological age (much greater than healthy control or airways disease counterparts)

doi.org/10.1183/1399...