Gio Fidelito
@gfidelito.bsky.social
Prostate Cancer. Metabolism. Lipid. Liver fibrosis.
University of Melbourne. 🇮🇩🇦🇺
University of Melbourne. 🇮🇩🇦🇺
Pinned
Gio Fidelito
@gfidelito.bsky.social
· Mar 27
Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth
Fidelito et al. conducted lipid-metabolism-focused CRISPR screens and identified the
dependency of prostate cancer on enzymes involved in the mevalonate pathway. Further
validation identified NUS1 as ...
www.cell.com
Excited to share that the final research chapter of my thesis is now published!
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
Excited to share that the final research chapter of my thesis is now published!
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
Lipid-metabolism-focused CRISPR screens identify enzymes of the mevalonate pathway as essential for prostate cancer growth
Fidelito et al. conducted lipid-metabolism-focused CRISPR screens and identified the
dependency of prostate cancer on enzymes involved in the mevalonate pathway. Further
validation identified NUS1 as ...
www.cell.com
March 27, 2025 at 2:28 AM
Excited to share that the final research chapter of my thesis is now published!
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
Our study explored which aspects of lipid metabolism are required for prostate cancer. The findings offer intriguing insights and many unanswered questions.
If you're interested in prostate cancer metabolism, please read the review article we wrote several years ago. I believe it's a good introduction for newcomers.
Frontiers | Personalized Medicine for Prostate Cancer: Is Targeting Metabolism a Reality?
Prostate cancer invokes major shifts in gene transcription and metabolic signaling to mediate alterations in nutrient acquisition and metabolic substrate sel...
www.frontiersin.org
December 16, 2024 at 9:25 PM
If you're interested in prostate cancer metabolism, please read the review article we wrote several years ago. I believe it's a good introduction for newcomers.
Excited to see this collaborative work published! We identify how changes in hepatic lipid metabolism can alter peripheral metabolism. www.cell.com/cell-reports...
Lipidome profiling in advanced metabolic liver disease identifies phosphatidylserine synthase 1 as a regulator of hepatic lipoprotein metabolism
Anari et al. show that hepatic accumulation of phosphatidylserine (PS) is associated with hypertriglyceridemia in metabolic dysfunction-associated steatohepatitis (MASH). Increasing expression of PS synthase 1 (PSS1), an enzyme responsible for PS generation, remodels liver-derived lipoprotein composition, which inhibits lipid deposition in skeletal muscle, leading to systemic hypertriglyceridemia.
www.cell.com
December 11, 2024 at 10:22 PM
Excited to see this collaborative work published! We identify how changes in hepatic lipid metabolism can alter peripheral metabolism. www.cell.com/cell-reports...
I thought I'd like to introduce myself here. I recently completed my PhD from the University of Melbourne, where I delved into the complexity of prostate cancer metabolism. My research involved ex vivo metabolic tracing in PDX and lipid metabolism-focused CRISPR screen.
November 14, 2024 at 10:53 PM
I thought I'd like to introduce myself here. I recently completed my PhD from the University of Melbourne, where I delved into the complexity of prostate cancer metabolism. My research involved ex vivo metabolic tracing in PDX and lipid metabolism-focused CRISPR screen.