gerrycreager.bsky.social
@gerrycreager.bsky.social
Absolutely love this.
December 27, 2025 at 2:54 PM
Absolutely love this.
You likely have better, more recent references than I but...
DOI: 10.3389/fmicb.2022.1027015
DOI: 10.1128/jvi.01516-24
DOI: 10.3390/biom13091338
DOI: 10.1152/ajplung.00049.2022
DOI: 10.1002/jmv.28340
I have to depend on the literature.
DOI: 10.3389/fmicb.2022.1027015
DOI: 10.1128/jvi.01516-24
DOI: 10.3390/biom13091338
DOI: 10.1152/ajplung.00049.2022
DOI: 10.1002/jmv.28340
I have to depend on the literature.
December 6, 2025 at 5:40 AM
You likely have better, more recent references than I but...
DOI: 10.3389/fmicb.2022.1027015
DOI: 10.1128/jvi.01516-24
DOI: 10.3390/biom13091338
DOI: 10.1152/ajplung.00049.2022
DOI: 10.1002/jmv.28340
I have to depend on the literature.
DOI: 10.3389/fmicb.2022.1027015
DOI: 10.1128/jvi.01516-24
DOI: 10.3390/biom13091338
DOI: 10.1152/ajplung.00049.2022
DOI: 10.1002/jmv.28340
I have to depend on the literature.
3/3
Part of this was the fact that we were, early, depending on what amounted to case reports rather than larger samples. THAT posed a problem if you updated your opinion daily (or more often.
Part of this was the fact that we were, early, depending on what amounted to case reports rather than larger samples. THAT posed a problem if you updated your opinion daily (or more often.
December 6, 2025 at 5:23 AM
3/3
Part of this was the fact that we were, early, depending on what amounted to case reports rather than larger samples. THAT posed a problem if you updated your opinion daily (or more often.
Part of this was the fact that we were, early, depending on what amounted to case reports rather than larger samples. THAT posed a problem if you updated your opinion daily (or more often.
2/
Specifically, the information was coming so fast, if you kept up with the information available, you could see three or four conflicting reports in a given day, all credible, all well-written but with different conclusions.
Specifically, the information was coming so fast, if you kept up with the information available, you could see three or four conflicting reports in a given day, all credible, all well-written but with different conclusions.
December 6, 2025 at 5:23 AM
2/
Specifically, the information was coming so fast, if you kept up with the information available, you could see three or four conflicting reports in a given day, all credible, all well-written but with different conclusions.
Specifically, the information was coming so fast, if you kept up with the information available, you could see three or four conflicting reports in a given day, all credible, all well-written but with different conclusions.
I learned in a trial by fire, but because of my publications and conference presentations, I did have to learn how to speak to the audience that I had. We CAN learn how to do it, but there were issues with this particular case.
December 6, 2025 at 5:22 AM
I learned in a trial by fire, but because of my publications and conference presentations, I did have to learn how to speak to the audience that I had. We CAN learn how to do it, but there were issues with this particular case.
Contended early on that we lost credibility because of our failures in communication. Too many people got info from echo chambers and thought the findings were static and we didn't do a great job of communicating the uncertainty. We need to do better.
December 3, 2025 at 5:05 PM
Contended early on that we lost credibility because of our failures in communication. Too many people got info from echo chambers and thought the findings were static and we didn't do a great job of communicating the uncertainty. We need to do better.
Marc,
Nice summary and thanks for the references. I have been juggling chainsaws in a couple of other areas for the last year and had not kept up as well as I should with my reading. Your references mean I can start that process pretty quickly.
Nice summary and thanks for the references. I have been juggling chainsaws in a couple of other areas for the last year and had not kept up as well as I should with my reading. Your references mean I can start that process pretty quickly.
December 3, 2025 at 5:04 PM
Marc,
Nice summary and thanks for the references. I have been juggling chainsaws in a couple of other areas for the last year and had not kept up as well as I should with my reading. Your references mean I can start that process pretty quickly.
Nice summary and thanks for the references. I have been juggling chainsaws in a couple of other areas for the last year and had not kept up as well as I should with my reading. Your references mean I can start that process pretty quickly.
I didn't feel a need to write another 5-10 comments. There remain questions of suppression of immune response post infection. We're still learning about coronavirus in general and this one specifically which seems to not be following understood pathways.
October 13, 2025 at 1:07 PM
I didn't feel a need to write another 5-10 comments. There remain questions of suppression of immune response post infection. We're still learning about coronavirus in general and this one specifically which seems to not be following understood pathways.
That's not what the article, or I said. It suggests the disease is not necessarily resolved when overt clinical symptoms resolve.
October 13, 2025 at 1:01 PM
That's not what the article, or I said. It suggests the disease is not necessarily resolved when overt clinical symptoms resolve.
One of several examples:
pubmed.ncbi.nlm.nih.gov/37283920
pubmed.ncbi.nlm.nih.gov/37283920
October 13, 2025 at 12:56 PM
One of several examples:
pubmed.ncbi.nlm.nih.gov/37283920
pubmed.ncbi.nlm.nih.gov/37283920
Several significant study limitations, not the least of which was self-reporting an infection. While the 1:1 comparison is reasonable from a study design, I actually would have preferred to see a larger control group. I didn't find this study completely convincing but it may be hypothesis generating
October 13, 2025 at 12:46 PM
Several significant study limitations, not the least of which was self-reporting an infection. While the 1:1 comparison is reasonable from a study design, I actually would have preferred to see a larger control group. I didn't find this study completely convincing but it may be hypothesis generating
Interesting take but I'm not sure I completely agree. Younger patients also see significant adverse result when infected, including immune response overall, harboring latent virus in solid organs, and systemic inflammatory processes. Vaccination still reduces significant morbidity in these patients.
October 13, 2025 at 12:39 PM
Interesting take but I'm not sure I completely agree. Younger patients also see significant adverse result when infected, including immune response overall, harboring latent virus in solid organs, and systemic inflammatory processes. Vaccination still reduces significant morbidity in these patients.
The question is, did Cedars-Sinai declare he had reached the limit, or did insurance declare he'd reached the end of coverage? What I inferred (always dangerous, of course) from his answer was that insurance said he was done.
October 13, 2025 at 12:33 PM
The question is, did Cedars-Sinai declare he had reached the limit, or did insurance declare he'd reached the end of coverage? What I inferred (always dangerous, of course) from his answer was that insurance said he was done.
Essentially ruining the ability to respond to outbreaks in a coherent fashion.
October 13, 2025 at 12:29 PM
Essentially ruining the ability to respond to outbreaks in a coherent fashion.
And yet, "nearly half" is not nearly enough. We need more vaccine acceptance by all ages.
January 9, 2025 at 4:38 PM
And yet, "nearly half" is not nearly enough. We need more vaccine acceptance by all ages.
Like this approach.
And: Having fought urban fires, I've not only seen water mains go dry when demand exceeded supply, I've seen mains collapse. It's a very local supply issue, not a statewide issue, nor one that bears politicizing, except to refute nonsense.
And: Having fought urban fires, I've not only seen water mains go dry when demand exceeded supply, I've seen mains collapse. It's a very local supply issue, not a statewide issue, nor one that bears politicizing, except to refute nonsense.
January 9, 2025 at 4:36 PM
Like this approach.
And: Having fought urban fires, I've not only seen water mains go dry when demand exceeded supply, I've seen mains collapse. It's a very local supply issue, not a statewide issue, nor one that bears politicizing, except to refute nonsense.
And: Having fought urban fires, I've not only seen water mains go dry when demand exceeded supply, I've seen mains collapse. It's a very local supply issue, not a statewide issue, nor one that bears politicizing, except to refute nonsense.
I'm migrating now. Gotta figure out how to retrieve all those posts I bookmarked over in the swampland.
November 16, 2024 at 2:41 AM
I'm migrating now. Gotta figure out how to retrieve all those posts I bookmarked over in the swampland.
No, you're over-credentialed for the position.
November 16, 2024 at 2:39 AM
No, you're over-credentialed for the position.
“he’s just asking questions, what’s wrong with that”
Because his questions are inane and nonsensical. Because he's a lawyer, lacks knowledge of virology and immunology. And because he's crazy.
Because his questions are inane and nonsensical. Because he's a lawyer, lacks knowledge of virology and immunology. And because he's crazy.
November 16, 2024 at 2:37 AM
“he’s just asking questions, what’s wrong with that”
Because his questions are inane and nonsensical. Because he's a lawyer, lacks knowledge of virology and immunology. And because he's crazy.
Because his questions are inane and nonsensical. Because he's a lawyer, lacks knowledge of virology and immunology. And because he's crazy.
But at the same time, the cellular immune system is "trained up" and responds when activated. That's your long-term immunity. IgG derived from vaccination is transient.
January 3, 2024 at 9:35 PM
But at the same time, the cellular immune system is "trained up" and responds when activated. That's your long-term immunity. IgG derived from vaccination is transient.
Congratulations! Nice work!
July 16, 2023 at 12:59 PM
Congratulations! Nice work!