Publisher: Julio Licinio, MD, PhD, MBA, MS.
https://genomicpress.com/
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Paper is 100% open access — go read it right now:
🔗 doi.org/10.61373/gp0...
Massive congrats to Karthikeyan Tangavelou, Kiran Bhaskar, Francesca-Fang Liao and team!
This one is going to run.
#Alzheimers #Tau #Neuroscience #Brain #Biotech
Paper is 100% open access — go read it right now:
🔗 doi.org/10.61373/gp0...
Massive congrats to Karthikeyan Tangavelou, Kiran Bhaskar, Francesca-Fang Liao and team!
This one is going to run.
#Alzheimers #Tau #Neuroscience #Brain #Biotech
Media lost their minds in <72 hours
Already on MSN.com (US + UK), AP news wire (worldwide), Medical Xpress, Drug Target Review + Spanish/Portuguese -language outlets
Screenshot proof 👇
Media lost their minds in <72 hours
Already on MSN.com (US + UK), AP news wire (worldwide), Medical Xpress, Drug Target Review + Spanish/Portuguese -language outlets
Screenshot proof 👇
RNA-seq on OTULIN-KO cells = absolute carnage
↓ 13,341 genes
↑ 774 genes
43,003 RNA transcripts wrecked
OTULIN is secretly one of the master regulators of RNA life & death in neurons. Nobody saw this coming.
RNA-seq on OTULIN-KO cells = absolute carnage
↓ 13,341 genes
↑ 774 genes
43,003 RNA transcripts wrecked
OTULIN is secretly one of the master regulators of RNA life & death in neurons. Nobody saw this coming.
CRISPR knockout of OTULIN = nuclear option
Result:
→ Total tau protein undetectable
→ MAPT mRNA (the gene) undetectable on qPCR
→ Zero cell death, perfect neuronal morphology
Tau was never even transcribed.
CRISPR knockout of OTULIN = nuclear option
Result:
→ Total tau protein undetectable
→ MAPT mRNA (the gene) undetectable on qPCR
→ Zero cell death, perfect neuronal morphology
Tau was never even transcribed.
Patient-derived Alzheimer’s neurons normally have:
🔥 Sky-high OTULIN protein
🔥 Sky-high phospho-tau (AT8, AT180, PHF-1)
One new drug-like molecule (UC495) ➜ slashed pathogenic tau in these actual human AD neurons.
Patient-derived Alzheimer’s neurons normally have:
🔥 Sky-high OTULIN protein
🔥 Sky-high phospho-tau (AT8, AT180, PHF-1)
One new drug-like molecule (UC495) ➜ slashed pathogenic tau in these actual human AD neurons.
They went in thinking:
“Block OTULIN → keep more ubiquitin on tau → cells clear toxic tangles faster.”
What actually happened when they knocked OTULIN out?
Tau protein = GONE
Tau mRNA = GONE
Neurons = still 100% happy and healthy
The brain simply stopped making tau.
They went in thinking:
“Block OTULIN → keep more ubiquitin on tau → cells clear toxic tangles faster.”
What actually happened when they knocked OTULIN out?
Tau protein = GONE
Tau mRNA = GONE
Neurons = still 100% happy and healthy
The brain simply stopped making tau.
🧠 THIS JUST BROKE THE INTERNET IN ALZHEIMER’S RESEARCH
A brand-new paper (published 3 days ago) shows we had tau completely wrong.
The enzyme **OTULIN** doesn’t just control inflammation…
It CONTROLS WHETHER YOUR BRAIN EVEN MAKES TAU PROTEIN.
Link: doi.org/10.61373/gp0...
🧠 THIS JUST BROKE THE INTERNET IN ALZHEIMER’S RESEARCH
A brand-new paper (published 3 days ago) shows we had tau completely wrong.
The enzyme **OTULIN** doesn’t just control inflammation…
It CONTROLS WHETHER YOUR BRAIN EVEN MAKES TAU PROTEIN.
Link: doi.org/10.61373/gp0...
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Check the interviews: interviews.genomicpress.com
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100+ Exclusive Interviews • Academy Members to Rising Stars • 20+ Countries
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Social media reach: 12+M
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Clinical questions this raises:
Should patients avoid caffeine before ketamine/ECT treatments?
Does chronic coffee consumption actually help prevent depression?
Can we leverage adenosine dynamics as a treatment biomarker?
Brain Medicine: bm.genomicpress.com
Genomic Press: genomicpress.com
Clinical questions this raises:
Should patients avoid caffeine before ketamine/ECT treatments?
Does chronic coffee consumption actually help prevent depression?
Can we leverage adenosine dynamics as a treatment biomarker?
Brain Medicine: bm.genomicpress.com
Genomic Press: genomicpress.com
THE COFFEE PARADOX ☕
Here's where it gets fascinating:
Coffee consumption → 20-25% reduced depression (protective through tonic adenosine receptor modulation)
BUT
Acute caffeine intake → may interfere with phasic adenosine surges during treatment
Same receptors, opposite clinical implications!
THE COFFEE PARADOX ☕
Here's where it gets fascinating:
Coffee consumption → 20-25% reduced depression (protective through tonic adenosine receptor modulation)
BUT
Acute caffeine intake → may interfere with phasic adenosine surges during treatment
Same receptors, opposite clinical implications!
Non-pharmacological breakthrough:
Acute intermittent hypoxia (5 cycles of controlled oxygen reduction, 3 days) produces antidepressant effects entirely dependent on adenosine signaling.
Safe, non-invasive, scalable—especially valuable for low-resource settings. 🌍
Non-pharmacological breakthrough:
Acute intermittent hypoxia (5 cycles of controlled oxygen reduction, 3 days) produces antidepressant effects entirely dependent on adenosine signaling.
Safe, non-invasive, scalable—especially valuable for low-resource settings. 🌍
Translation to therapeutics was immediate:
The team synthesized 31 ketamine derivatives and identified deschloroketamine (DCK): • Effective at 2 mg/kg (vs 10 mg/kg for ketamine)
• 40-80% stronger adenosine signals • Minimal psychomimetic side effects
Better therapeutic window = safer treatment 💊
Translation to therapeutics was immediate:
The team synthesized 31 ketamine derivatives and identified deschloroketamine (DCK): • Effective at 2 mg/kg (vs 10 mg/kg for ketamine)
• 40-80% stronger adenosine signals • Minimal psychomimetic side effects
Better therapeutic window = safer treatment 💊
Key finding: It's NOT about NMDA receptors!
Ketamine acts by directly modulating mitochondrial metabolism → increasing intracellular adenosine → transporter-mediated release.
This happens WITHOUT neuronal hyperactivity, overturning assumptions about seizure-like activity being necessary.
Key finding: It's NOT about NMDA receptors!
Ketamine acts by directly modulating mitochondrial metabolism → increasing intracellular adenosine → transporter-mediated release.
This happens WITHOUT neuronal hyperactivity, overturning assumptions about seizure-like activity being necessary.
Professor Min-Min Luo's team discovered that ketamine, ECT, and acute intermittent hypoxia—three completely different interventions—all work through the SAME mechanism: adenosine surges in mood-regulatory brain circuits.
Ketamine (10 mg/kg) triggered ~15% adenosine increases.
Professor Min-Min Luo's team discovered that ketamine, ECT, and acute intermittent hypoxia—three completely different interventions—all work through the SAME mechanism: adenosine surges in mood-regulatory brain circuits.
Ketamine (10 mg/kg) triggered ~15% adenosine increases.
☕🧠 THE COFFEE PARADOX IN DEPRESSION TREATMENT
New Brain Medicine commentary highlights Nature research revealing adenosine as the master regulator of rapid antidepressant action—creating a fascinating clinical dilemma.
Our analysis: dx.doi.org/10.61373/bm0...
Nature: doi.org/10.1038/s415...
☕🧠 THE COFFEE PARADOX IN DEPRESSION TREATMENT
New Brain Medicine commentary highlights Nature research revealing adenosine as the master regulator of rapid antidepressant action—creating a fascinating clinical dilemma.
Our analysis: dx.doi.org/10.61373/bm0...
Nature: doi.org/10.1038/s415...
Journal: bm.genomicpress.com
Publisher: genomicpress.com
This is what real-time scientific impact looks like in 2025. 🚀
Also: your gut bacteria are running more of your life than you think. Sleep well (with help from your microbiome).
(8/8)
Journal: bm.genomicpress.com
Publisher: genomicpress.com
This is what real-time scientific impact looks like in 2025. 🚀
Also: your gut bacteria are running more of your life than you think. Sleep well (with help from your microbiome).
(8/8)
🇺🇸 scienmag.com/new-study-unc...
🇮🇹 www.repubblica.it/salute/2025/...
🇫🇷 www.pourquoidocteur.fr/Articles/Que...
🇪🇸 www.eleconomista.es/salud-bienes...
🇨🇳 www.163.com/dy/article/K...
🇦🇿 baku.ws/en/this-is-i...
Real international reach, not just Anglosphere.
(5/8)
🇺🇸 scienmag.com/new-study-unc...
🇮🇹 www.repubblica.it/salute/2025/...
🇫🇷 www.pourquoidocteur.fr/Articles/Que...
🇪🇸 www.eleconomista.es/salud-bienes...
🇨🇳 www.163.com/dy/article/K...
🇦🇿 baku.ws/en/this-is-i...
Real international reach, not just Anglosphere.
(5/8)
His single post → 41,000 views of the paper.
That's the power of engaged science communication meeting genuinely interesting research.
(4/8)
His single post → 41,000 views of the paper.
That's the power of engaged science communication meeting genuinely interesting research.
(4/8)
Probiotics as clinical interventions
Fecal microbiota transplantation for insomnia
Targeting bile acid metabolism for circadian disorders
Actual paradigm shift territory.
(3/8)
Probiotics as clinical interventions
Fecal microbiota transplantation for insomnia
Targeting bile acid metabolism for circadian disorders
Actual paradigm shift territory.
(3/8)
Your gut bacteria are literally producing GABA and serotonin—neurotransmitters that control your sleep.
Science is weird and cool.
(2/8)
Your gut bacteria are literally producing GABA and serotonin—neurotransmitters that control your sleep.
Science is weird and cool.
(2/8)
(1/8)
(1/8)
🔬 First time ever: Peer-reviewed study by Soreq's group shows neurons survive botulinum via 335 protective RNA fragments in human cells. 20% share identical motif blocking ferroptosis. Changes treatment possibilities.
Read: doi.org/10.61373/gp0...
Source: genomicpress.kglmeridian.com
🔬 First time ever: Peer-reviewed study by Soreq's group shows neurons survive botulinum via 335 protective RNA fragments in human cells. 20% share identical motif blocking ferroptosis. Changes treatment possibilities.
Read: doi.org/10.61373/gp0...
Source: genomicpress.kglmeridian.com