Brian Geiss
@geisslaboratory.bsky.social
Virology, biochemistry, theoretical chemistry, engineering, and whatever else interests me. Including whisk(e)y. Alignment = Chaotic good
http://www.cvmbs.colostate.edu/ns/departments/mip/geiss_lab/index
http://www.cvmbs.colostate.edu/ns/departments/mip/geiss_lab/index
Pinned
Brian Geiss
@geisslaboratory.bsky.social
· Jul 17
@geisslaboratory.bsky.social at ASV is a success! Great times with great people, and everyone has done an amazing job!
Exciting new preprint led by Chasity Trammell where we use ancestral sequence reconstruction to generate a novel vaccine that provides broad-spectrum protection against tick-borne flaviviruses. Great collaboration with @ebellaboratory.bsky.social group!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Generation of broad-spectrum vaccine platforms against tick-borne flaviviruses using ancestral sequence reconstruction
Tick-Borne Flaviviruses (TBFs) pose a significant global health threat, but few vaccines exist against these viral pathogens. Currently approved vaccines against TBFs are only protective against speci...
www.biorxiv.org
November 2, 2025 at 1:42 PM
Exciting new preprint led by Chasity Trammell where we use ancestral sequence reconstruction to generate a novel vaccine that provides broad-spectrum protection against tick-borne flaviviruses. Great collaboration with @ebellaboratory.bsky.social group!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
And here's some more ASV2025 photos
July 17, 2025 at 6:18 PM
And here's some more ASV2025 photos
@geisslaboratory.bsky.social at ASV is a success! Great times with great people, and everyone has done an amazing job!
July 17, 2025 at 4:50 AM
@geisslaboratory.bsky.social at ASV is a success! Great times with great people, and everyone has done an amazing job!
Reposted by Brian Geiss
Off to Montreal for #ASV2025 with the @geisslaboratory.bsky.social! I have a talk on Tuesday, be sure to stop by! :)
July 13, 2025 at 3:45 PM
Off to Montreal for #ASV2025 with the @geisslaboratory.bsky.social! I have a talk on Tuesday, be sure to stop by! :)
Reposted by Brian Geiss
Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with
@martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org
🧬 Code will be released in a couple weeks
@martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org
🧬 Code will be released in a couple weeks
April 8, 2025 at 12:17 PM
Excited to share our preprint “BoltzDesign1: Inverting All-Atom Structure Prediction Model for Generalized Biomolecular Binder Design” — a collaboration with
@martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org
🧬 Code will be released in a couple weeks
@martinpacesa.bsky.social, @Zhidian Zhang, @Bruno E. Correia, and @sokrypton.org
🧬 Code will be released in a couple weeks
Kay does amazing work, great lab to work in!
Post-doc position is available in Choi laboratory at IU. Our research focuses on the structure and function of viral RNAs & replication. Experience in biochemistry or structural biology (X-ray crystallography & cryoEM) is required. Please send cover letter and CV to kaychoi@iu.edu
Please repost.
Please repost.
March 29, 2025 at 1:43 AM
Kay does amazing work, great lab to work in!
Cool crystal structure of the coxsackievirus cloverleaf RNA and 3C protease from my friend Kay Choi's lab!
How does enterovirus protease specifically recognize its viral RNA genome?
Hint: It takes two!
Our first post on bluesky - Happy to share our new publication.
Structure of coxsackievirus cloverleaf RNA and 3C protease dimer establishes its RNA-binding mechanism
www.science.org/doi/10.1126/...
Hint: It takes two!
Our first post on bluesky - Happy to share our new publication.
Structure of coxsackievirus cloverleaf RNA and 3C protease dimer establishes its RNA-binding mechanism
www.science.org/doi/10.1126/...
March 22, 2025 at 4:41 PM
Cool crystal structure of the coxsackievirus cloverleaf RNA and 3C protease from my friend Kay Choi's lab!
Reposted by Brian Geiss
Hi folks, to those teaching courses where it is useful to know the one letter amino acid code, I used Suno to make a mnemonic song (Bossa nova style...)
suno.com/song/8ce2f2e...
suno.com/song/8ce2f2e...
Amino Acids by @entertainingchurchchoir073 | Suno
1960s bossa nova song. Listen and make your own with Suno.
suno.com
November 17, 2024 at 9:10 PM
Hi folks, to those teaching courses where it is useful to know the one letter amino acid code, I used Suno to make a mnemonic song (Bossa nova style...)
suno.com/song/8ce2f2e...
suno.com/song/8ce2f2e...
Reposted by Brian Geiss
Fort Collins and Northern Colorado. Join us on Friday, March 7 at 12:00pm to #StandUpForScience2025. Visit the local website of CSU STEM Interdisciplinary Ram Alliance for local press release, printable posters, and opportunities to get involved - beacons.ai/csu_sira/sta...
March 6, 2025 at 3:38 PM
Fort Collins and Northern Colorado. Join us on Friday, March 7 at 12:00pm to #StandUpForScience2025. Visit the local website of CSU STEM Interdisciplinary Ram Alliance for local press release, printable posters, and opportunities to get involved - beacons.ai/csu_sira/sta...
Reposted by Brian Geiss
Very pleased with this ProteinMPNN-based collaboration that ballooned to encompass an impressive number of redesigned proteins for intracellular biomolecular recognition! www.biorxiv.org/content/10.1...
www.biorxiv.org
February 11, 2025 at 11:18 PM
Very pleased with this ProteinMPNN-based collaboration that ballooned to encompass an impressive number of redesigned proteins for intracellular biomolecular recognition! www.biorxiv.org/content/10.1...
Reposted by Brian Geiss
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 12, 2025 at 6:28 AM
Making intrabodies from antibodies just got easier! Learn how we made 𝟭𝟵 intrabodies to bind and light up peptides and histone modifications in live cells. And thanks to Academia, all sequences are freely available. (video credit: Yuko Sato @YukoSatoT2) (1/15)
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...