Grant Glatfelter
@gcglatfelter.bsky.social
DDRU - pharmacology, drug discovery, NPS, psychedelics, cannabinoids, opioids, stimulants, entactogens, circadian biology.
Views are my own & follows 🚫= endorsement.
https://scholar.google.com/citations?hl=en&user=v3rjnvAAAAAJ
Views are my own & follows 🚫= endorsement.
https://scholar.google.com/citations?hl=en&user=v3rjnvAAAAAJ
Out now in Mol Psych -
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
nature.com/articles/s4138…#psychedelicsc#pharmacologygy
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
nature.com/articles/s4138…#psychedelicsc#pharmacologygy
https://nature.com/articles/s4138…
November 5, 2025 at 8:42 PM
Out now in Mol Psych -
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
nature.com/articles/s4138…#psychedelicsc#pharmacologygy
The 4-alkyl chain length of 2,5-dimethoxyamphetamines differentially affects in vitro serotonin receptor actions versus in vivo psychedelic-like effects
nature.com/articles/s4138…#psychedelicsc#pharmacologygy
September 3, 2025 at 3:22 PM
Our pub describing an approach to quantify the head twitch response in mice from video recordings using the open-source machine learning-based toolkits DeepLabCut and SimBA is out now in ACS Pharm Trans Sci!
pubs.acs.org/doi/full/10....
#psychedelics #HTR #machinelearning
pubs.acs.org/doi/full/10....
#psychedelics #HTR #machinelearning
August 1, 2025 at 3:27 PM
Our pub describing an approach to quantify the head twitch response in mice from video recordings using the open-source machine learning-based toolkits DeepLabCut and SimBA is out now in ACS Pharm Trans Sci!
pubs.acs.org/doi/full/10....
#psychedelics #HTR #machinelearning
pubs.acs.org/doi/full/10....
#psychedelics #HTR #machinelearning
Out now:
Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice
Check it out 👇
link.springer.com/article/10.1...
#psychedelics #HTR
Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice
Check it out 👇
link.springer.com/article/10.1...
#psychedelics #HTR
Psychedelic-like effects induced by 2,5-dimethoxy-4-iodoamphetamine, lysergic acid diethylamide, and psilocybin in male and female C57BL/6J mice - Psychopharmacology
Rationale The head twitch response (HTR) is a spontaneously occurring behavior in mice that is increased in frequency by serotonergic psychedelics. The mouse HTR is often used as a proxy for psychedel...
link.springer.com
May 19, 2025 at 11:19 AM
Out now:
Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice
Check it out 👇
link.springer.com/article/10.1...
#psychedelics #HTR
Psychedelic-like effects induced by DOI, LSD, and psilocybin in male and female C57BL/6J mice
Check it out 👇
link.springer.com/article/10.1...
#psychedelics #HTR
Reposted by Grant Glatfelter
Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis https://www.biorxiv.org/content/10.1101/2025.04.28.650242v1
May 1, 2025 at 6:01 PM
Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis https://www.biorxiv.org/content/10.1101/2025.04.28.650242v1
Excited to announce our preprint using machine learning-based toolkits to quantify the head-twitch response in mice.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Rapid, open-source, and automated quantification of the head twitch response in C57BL/6J mice using DeepLabCut and Simple Behavioral Analysis
Serotonergic psychedelics induce the head twitch response (HTR) in mice, an index of serotonin (5-HT) 2A receptor (5-HT2A) agonism and a behavioral proxy for psychedelic effects in humans. Existing me...
www.biorxiv.org
May 1, 2025 at 8:02 PM
Excited to announce our preprint using machine learning-based toolkits to quantify the head-twitch response in mice.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Catch us on Friday at the virtual ISRP meeting!
www.isrpsych.org/conferences
12:10 PM - 12:25 PM EDT
9:10 AM - 9:25 AM PDT
Michael Baumann
3:15 PM - 3:30 PM EDT
12:15 PM - 12:30 PM PDT
Grant Glatfelter
#DMT #4MeOMiPT #psychedelics
www.isrpsych.org/conferences
12:10 PM - 12:25 PM EDT
9:10 AM - 9:25 AM PDT
Michael Baumann
3:15 PM - 3:30 PM EDT
12:15 PM - 12:30 PM PDT
Grant Glatfelter
#DMT #4MeOMiPT #psychedelics
March 4, 2025 at 10:11 PM
Catch us on Friday at the virtual ISRP meeting!
www.isrpsych.org/conferences
12:10 PM - 12:25 PM EDT
9:10 AM - 9:25 AM PDT
Michael Baumann
3:15 PM - 3:30 PM EDT
12:15 PM - 12:30 PM PDT
Grant Glatfelter
#DMT #4MeOMiPT #psychedelics
www.isrpsych.org/conferences
12:10 PM - 12:25 PM EDT
9:10 AM - 9:25 AM PDT
Michael Baumann
3:15 PM - 3:30 PM EDT
12:15 PM - 12:30 PM PDT
Grant Glatfelter
#DMT #4MeOMiPT #psychedelics
Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs
doi.org/10.1093/jat/...
doi.org/10.1093/jat/...
Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs
Abstract. Identification of N,N-dimethylpentylone (DMP) in counterfeit “Ecstasy” and “Molly” tablets poses risk to public health due to its adverse effects
doi.org
February 12, 2025 at 12:22 AM
Toxicological evaluation, postmortem case descriptions, and pharmacological activity of N,N-dimethylpentylone and related analogs
doi.org/10.1093/jat/...
doi.org/10.1093/jat/...
🚨 Save the Date! 🚨
I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐
✨ 24 presentations
✨ Register here today - www.isrpsych.org/store
#Psychedelics #PsychedelicResearch #ISRP2025
I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐
✨ 24 presentations
✨ Register here today - www.isrpsych.org/store
#Psychedelics #PsychedelicResearch #ISRP2025
Store — International Society for Research on Psychedelics
www.isrpsych.org
January 15, 2025 at 11:46 PM
🚨 Save the Date! 🚨
I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐
✨ 24 presentations
✨ Register here today - www.isrpsych.org/store
#Psychedelics #PsychedelicResearch #ISRP2025
I'm speaking about 4-HO-MiPT analogs at the upcoming International Society of Research on Psychedelics (ISRP) virtual conference on March 7, 2025! 🌐
✨ 24 presentations
✨ Register here today - www.isrpsych.org/store
#Psychedelics #PsychedelicResearch #ISRP2025
New pub in ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities & target profiles of #5MeODMT analogs
Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans.
pubs.acs.org/doi/full/10....
Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans.
pubs.acs.org/doi/full/10....
December 5, 2024 at 2:53 PM
New pub in ACSChemNeurosci comparing 5-HT1A & 5-HT2A activities & target profiles of #5MeODMT analogs
Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans.
pubs.acs.org/doi/full/10....
Variable activities at 1A/2A modulated #psychedelic -like effects in mice, and 1A preferring hybrid 1A/2A drugs may have attenuated subjective effects in humans.
pubs.acs.org/doi/full/10....
Reposted by Grant Glatfelter
A recent review of 5-HT2A receptor SAR from Dr. Dave :)
BPS Publications
This brief review highlights some of the structure–activity relationships of classic serotonergic psychedelics. In particular, we discuss structural features of three chemotypes: phenethylamines, erg...
bpspubs.onlinelibrary.wiley.com
November 22, 2024 at 12:59 PM
A recent review of 5-HT2A receptor SAR from Dr. Dave :)
Reposted by Grant Glatfelter
Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid
Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act.
psychedelicalpha.com/news/dispatc...
Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act.
psychedelicalpha.com/news/dispatc...
Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid - Psychedelic Alpha
In a quiet courtroom housed on the second floor of the Drug Enforcement Agency’s (DEA) Museum and Visitors Center in Arlington, Virginia, a legal battle is unfolding over the status of two key…
psychedelicalpha.com
November 18, 2024 at 10:36 PM
Dispatch From the DEA: DOI and DOC on Trial As Scientists Challenge Psychedelic Scheduling Bid
Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act.
psychedelicalpha.com/news/dispatc...
Here, @jackgorsline.bsky.social and I provide the latest from hearings over DEA’s plan to place these two psychedelics in Schedule I of the Controlled Substances Act.
psychedelicalpha.com/news/dispatc...
1) Drug discovery, medication development, new psychoactive substances, preclinical research
2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞
3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it
2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞
3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it
Bluesky Psychedelics People: Let's (re-)intro ourselves to one another!
Quote this post and tell us:
1) What you do in the field
2) A project you're currently working on
3) A show/film/book you're enjoying
Quote this post and tell us:
1) What you do in the field
2) A project you're currently working on
3) A show/film/book you're enjoying
November 18, 2024 at 3:37 AM
1) Drug discovery, medication development, new psychoactive substances, preclinical research
2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞
3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it
2) SAR study on 5-MeO-DMT analogs that should hopefully be out soon 🤞
3) I went back and rewatched "Dirty Pictures" recently, which I highly recommend for anyone who hasn't seen it
Check out our new publication on the pharmacological characterization of novel, "prophetic" nitazene synthetic #opioids - some of which were found to be more potent than #fentanyl!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Characterization of novel nitazene recreational drugs: Insights into their risk potential from in vitro µ-opioid receptor assays and in vivo behavioral studies in mice
2-Benzylbenzimidazole derivatives or ‘nitazenes’ are increasingly present on the recreational drug market. Here, we report the synthesis and pharmacol…
www.sciencedirect.com
November 18, 2024 at 3:17 AM
Check out our new publication on the pharmacological characterization of novel, "prophetic" nitazene synthetic #opioids - some of which were found to be more potent than #fentanyl!
www.sciencedirect.com/science/arti...
www.sciencedirect.com/science/arti...
Reposted by Grant Glatfelter
Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:
www.usonainstitute.org/updates/uson...
www.usonainstitute.org/updates/uson...
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
January 10, 2024 at 6:18 PM
Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:
www.usonainstitute.org/updates/uson...
www.usonainstitute.org/updates/uson...
Reposted by Grant Glatfelter
A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎
www.science.org/content/blog...
www.science.org/content/blog...
An LSD Comparison
LSD itself, then, is not a natural product. And neither is the compound to the right of it - that's lisuride, which was synthesized in the early 1960s. A lot of work has been done on this chemical framework, and lisuride itself has been marketed as a drug over the years for migraine and several other indications. It has no hallucinogenic effects, though.
www.science.org
February 9, 2024 at 2:04 PM
A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎
www.science.org/content/blog...
www.science.org/content/blog...
A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎
www.science.org/content/blog...
www.science.org/content/blog...
An LSD Comparison
LSD itself, then, is not a natural product. And neither is the compound to the right of it - that's lisuride, which was synthesized in the early 1960s. A lot of work has been done on this chemical framework, and lisuride itself has been marketed as a drug over the years for migraine and several other indications. It has no hallucinogenic effects, though.
www.science.org
February 9, 2024 at 2:04 PM
A really nice synopsis of our recently published study on lisuride vs LSD from Derek Lowe for "In The Pipeline" 😎
www.science.org/content/blog...
www.science.org/content/blog...
Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:
www.usonainstitute.org/updates/uson...
www.usonainstitute.org/updates/uson...
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
January 10, 2024 at 6:18 PM
Release from Usona Institute about our collaborative study of the psychedelic -like effects of norpsilocin analogues:
www.usonainstitute.org/updates/uson...
www.usonainstitute.org/updates/uson...
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
January 8, 2024 at 3:54 PM
Thrilled to share the final product for an excellent collaboration with A. Sherwood & co at Usona Institute 😎.
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Extending norpsilocin by a single methyl group to N-ethyl is sufficient for psychedelic-like activity in mice. Full story & SAR linked below:
pubs.acs.org/doi/10.1021/...
Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-metha...
Molecular Psychiatry - Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone
www.nature.com
January 2, 2024 at 8:39 PM
Unique pharmacodynamic properties and low abuse liability of the µ-opioid receptor ligand (S)-methadone
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Excited to announce that I'm being promoted to a full-time federal employee in the DDRU to continue research on new psychoactive substances for the foreseeable future 🙌. Grateful for all of the support from NIDA IRP and Mike Baumann to make it possible 🙏
November 8, 2023 at 1:02 PM
Excited to announce that I'm being promoted to a full-time federal employee in the DDRU to continue research on new psychoactive substances for the foreseeable future 🙌. Grateful for all of the support from NIDA IRP and Mike Baumann to make it possible 🙏
The chronobiologist in me wants to highlight the importance of the Dictionary.com word of the day yesterday. Zeitgebers matter for all biological research.
Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.
Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.
November 6, 2023 at 4:26 PM
The chronobiologist in me wants to highlight the importance of the Dictionary.com word of the day yesterday. Zeitgebers matter for all biological research.
Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.
Many ignore the influence of zeitgebers in biomedical research - contributing to the replication crisis and misleading future research.
The important psychedelic and other research Roland lead at BPRU and his dedication to science will never be forgotten - RIP.
His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚
hub.jhu.edu/2023/10/18/r...
His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚
hub.jhu.edu/2023/10/18/r...
Pioneering psychedelics researcher Roland Griffiths dies at 77
His work with psychedelic and mood-altering drugs generated immense scientific interest, helped patients suffering with depression and addiction
hub.jhu.edu
October 18, 2023 at 7:04 PM
The important psychedelic and other research Roland lead at BPRU and his dedication to science will never be forgotten - RIP.
His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚
hub.jhu.edu/2023/10/18/r...
His team at BPRU changed my life forever by giving me a shot to work there early in my career. TY 💚
hub.jhu.edu/2023/10/18/r...
Finally made it to bluesy thanks to @alexkwan.bsky.social!
Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.
Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.
October 18, 2023 at 7:03 PM
Finally made it to bluesy thanks to @alexkwan.bsky.social!
Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.
Follow me for updates on and discussion of research regarding the pharmacology of psychedelics, opioids, cannabinoids, stimulants, and melatonergic drugs.