These anxiety-like behaviours were reduced using an anxiety-relieving drug. Therefore, the new TIDAL conflict test unmasks sex differences in mouse anxiety-like behaviour, and could identify new mechanisms and treatments for anxiety.
4/5

Our data reveal that females remain on the dark-heating plate for longer than males.
3/5

We created a new test with two chambers that places an anxiety-inducing stimulus—light—in conflict with heat. The dark chamber floor heats to uncomfortable temperatures, whereas the illuminated chamber temperature remains comfortable.
2/5

🚨New G-lab publication alert!🚨
Anxiety is twice as prevalent in women - yet these #sexdifferences are not reflected in preclinical tests for anxiety-like behaviour. We developed a new conflict test for rodents that unmasks these sex differences. #SABV doi.org/10.1002/jnr....
1/5

Thanks to Mission Connect for another great symposium in Houston!
Our lab enjoyed the posters, friends, and Jeff Twiss's seminar - as well as the breakfast tacos. 🧠🌮 See you again next year!