Connor Garrels
@garrels.bsky.social
PhD Candidate - Reichow Lab at OHSU
cryoET and whatever
He/Him
cryoET and whatever
He/Him
Reposted by Connor Garrels
#NIHFundedDiscovery
How do cells avoid the "kiss of death"?
Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.
#CryoEM reveals the molecular switches behind this process!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
How do cells avoid the "kiss of death"?
Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.
#CryoEM reveals the molecular switches behind this process!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
February 21, 2025 at 11:27 PM
#NIHFundedDiscovery
How do cells avoid the "kiss of death"?
Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.
#CryoEM reveals the molecular switches behind this process!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
How do cells avoid the "kiss of death"?
Gap junctions share life-saving signals—but under stress, they shut down to prevent spreading cytotoxic damage.
#CryoEM reveals the molecular switches behind this process!
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Connor Garrels
Super excited for this one! High-res #cryo-EM ensemble of sHSP/client complexes, uncovering 'Mechanism of small heat shock protein client sequestration and induced polydispersity'
www.biorxiv.org/content/10.1...
A teaser...👇
www.biorxiv.org/content/10.1...
A teaser...👇
December 6, 2024 at 4:49 PM
Super excited for this one! High-res #cryo-EM ensemble of sHSP/client complexes, uncovering 'Mechanism of small heat shock protein client sequestration and induced polydispersity'
www.biorxiv.org/content/10.1...
A teaser...👇
www.biorxiv.org/content/10.1...
A teaser...👇
Reposted by Connor Garrels
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
A timely release of this story... as it is a great setup to the next one, coming soon!!
Dynamic fibrillar assembly of αB-crystallin induced by perturbation of the conserved NT-IXI motif resolved by cryo-EM - Nature Communications
Here the authors show that mutating αB-crystallin’s NT-IXI motif transforms polydispersed oligomers into ordered fibrils, enabling cryo-EM to provide insights into the principles of high-order assembl...
www.nature.com
December 2, 2024 at 11:57 PM
Pleased to share the peer-reviewed version of our latest work on resolving the complexities of a-crystallins/sHSP's: www.nature.com/articles/s41...
A timely release of this story... as it is a great setup to the next one, coming soon!!
A timely release of this story... as it is a great setup to the next one, coming soon!!
Inaugural post sharing a newly updated version of our little protocol for high quality fiducial removal in #CryoET processing
Tomogram Reconstruction and Gold Fiducial Removal with WarpTools, Etomo, and Fidder
While gold nanoparticle fiducials greatly improve tilt-series alignment in cryo-electron tomography data, they can cause artifacts during later image processing steps. We presen...
www.protocols.io
December 2, 2024 at 8:31 PM
Inaugural post sharing a newly updated version of our little protocol for high quality fiducial removal in #CryoET processing