Gabriel Aughey
@gabrielaughey.bsky.social
Neurobiologist at UCL. Interested in neurological disease, genetics, behaviour, and development.
Thanks - I will!
July 23, 2025 at 3:03 PM
Thanks - I will!
That's good to hear - was mostly thinking about IHCs. If you haven't noticed any problems I'll make the change!
July 23, 2025 at 2:56 PM
That's good to hear - was mostly thinking about IHCs. If you haven't noticed any problems I'll make the change!
Amazing - we will definitely start doing this too! Have you tried for anything other than gel loading?
July 23, 2025 at 2:32 PM
Amazing - we will definitely start doing this too! Have you tried for anything other than gel loading?
Actually - looking at it again, I'm not sure this paper does actually show that they go around rather than between...!
July 15, 2025 at 9:41 AM
Actually - looking at it again, I'm not sure this paper does actually show that they go around rather than between...!
I think this is the paper that shows it: pmc.ncbi.nlm.nih.gov/articles/PMC.... I remember seeing a talk by Kim Naysmith ages ago who said he had the idea that the DNA goes through the ring from seeing climbing ropes going through a carabiner.
Closing the cohesin ring: structure and function of its Smc3-kleisin interface
Through their association with a kleisin subunit (Scc1), cohesin’s Smc1 and Smc3 subunits are thought to form tripartite rings that mediate sister chromatid cohesion. Unlike the structure of Smc1/Smc3...
pmc.ncbi.nlm.nih.gov
July 15, 2025 at 9:38 AM
I think this is the paper that shows it: pmc.ncbi.nlm.nih.gov/articles/PMC.... I remember seeing a talk by Kim Naysmith ages ago who said he had the idea that the DNA goes through the ring from seeing climbing ropes going through a carabiner.
Not sure if it is up-to-date, but there is this list via flybase: wiki.flybase.org/wiki/FlyBase... So looks around 2000, from this, but seems like it might be an underestimate to me.
FlyBase:Fly Lab List - FlyBase Wiki
wiki.flybase.org
March 6, 2025 at 1:25 PM
Not sure if it is up-to-date, but there is this list via flybase: wiki.flybase.org/wiki/FlyBase... So looks around 2000, from this, but seems like it might be an underestimate to me.
Rbf is a critical transcriptional regulator of the cell-cycle, so we were suprised to find important roles for Rbf in mature neurons long after cell-cycle exit. Please read the paper for more details (2/2).
February 21, 2025 at 11:34 AM
Rbf is a critical transcriptional regulator of the cell-cycle, so we were suprised to find important roles for Rbf in mature neurons long after cell-cycle exit. Please read the paper for more details (2/2).