Our work provides the exciting possibility of reintroducing fast-glycolytic type IIb myofibers—long absent in humans—through the manipulation of large MAFs!!
I’d like to thank Dr. Pascal Maire and Dr. Stefano Schiaffino for their invaluable comments on our study prior to submission.

Moreover, collaboration with Ildus
@SportsGenomics
RNA-seq analysis of human muscle biopsies revealed a nice positive correlation between MAFA, MAF, and MYH4 expression, with these genes elevated in power-trained individuals.

Interestingly, type IIb myofibers are largely absent in the skeletal muscles of humans, despite their significant role in smaller animals such as mice. However, large MAF can reawaken evolutionarily dormant fast-glycolytic Type IIb myofibers in human skeletal muscle.