Facundo Romani
@fromani.bsky.social
Leverhulme ECF (U of Cambridge)🇬🇧. PhD (UNL)🇦🇷Biotechnologist (UNQ)🇦🇷. Gene regulation and plant EvoDevo.
Some highlights of the wonderful visit to Huazhong Agricultural University. Great scientific discussions and the best food. Thanks professor Fei Zhang for hosting.
October 26, 2025 at 1:57 PM
Some highlights of the wonderful visit to Huazhong Agricultural University. Great scientific discussions and the best food. Thanks professor Fei Zhang for hosting.
Marchantia berteroana at 3000 meters above the sea level. Vallecitos, Mendoza.
September 12, 2025 at 11:35 PM
Marchantia berteroana at 3000 meters above the sea level. Vallecitos, Mendoza.
In Animals, TFs have a clear preference for certain chromatin states. With some tricks, we show that this could also be true in plants. This opens the possibility to distinguish TFs by their mode of action (pioneer vs normal TFs). This includes some unusual 5'UTR TFs.
July 21, 2025 at 5:16 PM
In Animals, TFs have a clear preference for certain chromatin states. With some tricks, we show that this could also be true in plants. This opens the possibility to distinguish TFs by their mode of action (pioneer vs normal TFs). This includes some unusual 5'UTR TFs.
Chromatin is highly conserved across eukaryotes, but it does not always work the same way. First, in both Arabidopsis and Marchantia, analogous chromatin states can be identified. Tissue-specific genes associate with TFs in facultative chromatin.h
July 21, 2025 at 5:16 PM
Chromatin is highly conserved across eukaryotes, but it does not always work the same way. First, in both Arabidopsis and Marchantia, analogous chromatin states can be identified. Tissue-specific genes associate with TFs in facultative chromatin.h
Marchantia has probably the most simple cell cycle control system ever described in plants and beyond. This has several evolutionary implications, it could help to unravel the system in flowering plants and find out how this system may work in ancestral eukaryotes.
March 14, 2025 at 9:16 AM
Marchantia has probably the most simple cell cycle control system ever described in plants and beyond. This has several evolutionary implications, it could help to unravel the system in flowering plants and find out how this system may work in ancestral eukaryotes.
Using overexpression, we characterized how these cyclins affect cell division. We found that MpCYCD;1 is the rate limiting cyclin; MpCYCD;2 is not functional; and surprisingly, MpCYCB;1 and MpCYCA arrest cell division. This means that they need to be degraded to complete the process.
March 14, 2025 at 9:16 AM
Using overexpression, we characterized how these cyclins affect cell division. We found that MpCYCD;1 is the rate limiting cyclin; MpCYCD;2 is not functional; and surprisingly, MpCYCB;1 and MpCYCA arrest cell division. This means that they need to be degraded to complete the process.
Is this true in vivo? We did translational reporters and validated this observation in vivo. Interestingly, CYCB is accumulated in the cytosol, but for a few minutes, it is translocated to the nuclei to start mitosis.
March 14, 2025 at 9:16 AM
Is this true in vivo? We did translational reporters and validated this observation in vivo. Interestingly, CYCB is accumulated in the cytosol, but for a few minutes, it is translocated to the nuclei to start mitosis.
During cell-cycle re-entry, only one of each cyclins is activated at a time. Looking at single cell data during progression, we manage to separate subclusters of three clear phases corresponding to G1, S, and G2/M. We find out that each cluster is governed by CYCD1/CDKA, CYCA/CDKA, and CYCB1/CDKB.
March 14, 2025 at 9:16 AM
During cell-cycle re-entry, only one of each cyclins is activated at a time. Looking at single cell data during progression, we manage to separate subclusters of three clear phases corresponding to G1, S, and G2/M. We find out that each cluster is governed by CYCD1/CDKA, CYCA/CDKA, and CYCB1/CDKB.
For example, in Arabidopsis you have 30 cyclins all over the place… Marchantia has a small set of cyclins, including 2 CYCD, 2 CYCB, and 1 CYCA. Phylogenetic analysis suggest that these genes are single copy in most related non-seed plant species too. (Why so many cyclins in flowering plants?)
March 14, 2025 at 9:16 AM
For example, in Arabidopsis you have 30 cyclins all over the place… Marchantia has a small set of cyclins, including 2 CYCD, 2 CYCB, and 1 CYCA. Phylogenetic analysis suggest that these genes are single copy in most related non-seed plant species too. (Why so many cyclins in flowering plants?)
In Eukaryotes, to coordinate replication with cell division, an elegant relay of cyclins and CDKs controls the transition between gap 1 (G1), replication (S), gap 2 (G2), to end in mitosis and start over again. You may have seen this plot in the Alberts manual, but is it true in any organism?
March 14, 2025 at 9:16 AM
In Eukaryotes, to coordinate replication with cell division, an elegant relay of cyclins and CDKs controls the transition between gap 1 (G1), replication (S), gap 2 (G2), to end in mitosis and start over again. You may have seen this plot in the Alberts manual, but is it true in any organism?
Liverwort gardening day
February 14, 2025 at 8:43 PM
Liverwort gardening day
Following this. (Hakone Gora Park, Japan)
January 27, 2025 at 9:22 AM
Following this. (Hakone Gora Park, Japan)
Random Marchantia picture of the week.
January 7, 2025 at 12:27 PM
Random Marchantia picture of the week.
What a day! Last session of the #nonseeduk24 #plantsciences. I hope everybody enjoyed beautiful Madingley Hall
December 16, 2024 at 5:51 PM
What a day! Last session of the #nonseeduk24 #plantsciences. I hope everybody enjoyed beautiful Madingley Hall
Getting ready for the Non-seed meeting in Cambridge @gensocuknonseed.bsky.social
December 11, 2024 at 1:50 PM
Getting ready for the Non-seed meeting in Cambridge @gensocuknonseed.bsky.social
This is not Cambridge yet but looks alike. Last stop of this trip, Rikkyo University in Tokyo.
November 26, 2024 at 5:35 PM
This is not Cambridge yet but looks alike. Last stop of this trip, Rikkyo University in Tokyo.
Almost time to go back home. We had a wonderful day visiting Keiko Sugimoto’s lab at RIKEN, talking about regeneration in all sort of plant species. #plantsciences #plantevodevo
November 25, 2024 at 12:50 PM
Almost time to go back home. We had a wonderful day visiting Keiko Sugimoto’s lab at RIKEN, talking about regeneration in all sort of plant species. #plantsciences #plantevodevo
The 2024 Marchantia Workshop in Hiroshima have finished with a liverwort hunting at Ryūzu Gorge. Congratulation Yuki and organizers for all the efforts. It is wonderful to grow with such a nice community. #PlantSciences #Marchantia #PlantEvoDevo
November 21, 2024 at 6:42 PM
The 2024 Marchantia Workshop in Hiroshima have finished with a liverwort hunting at Ryūzu Gorge. Congratulation Yuki and organizers for all the efforts. It is wonderful to grow with such a nice community. #PlantSciences #Marchantia #PlantEvoDevo
Barbara Da Costa from GMI closing the second day of the Marchantia Workshop #PlantSciences #Marchanfia
November 19, 2024 at 8:30 AM
Barbara Da Costa from GMI closing the second day of the Marchantia Workshop #PlantSciences #Marchanfia
The Marchantia workshop program is starting strong with Junko Kyozuka #PlantSciences #evodevo #Marchantia
November 18, 2024 at 4:53 AM
The Marchantia workshop program is starting strong with Junko Kyozuka #PlantSciences #evodevo #Marchantia
One more flight to Japan. It seems this social network is the only one that works in China. Cool!
November 16, 2024 at 9:37 PM
One more flight to Japan. It seems this social network is the only one that works in China. Cool!