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Freedom Wares
@freedomwares.bsky.social
29 followers 25 following 39 posts
Patient advocate and Independent researcher of the Endocannabinoid System & Cannabinopathic Medicine for over 2 decades. Home grown and Internationally known.
I.AM. Cannabian.
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freedomwares.bsky.social
The #ECS plays a key role in brain function, and research suggests it may be dysregulated in autism. #Cannabis helps some patients by reducing neuroinflammation, improving neurotransmitter balance and easing anxiety, sensory issues and sleep disturbances.

#Autism research: tinyurl.com/2supr4a3
April 2, 2025 at 6:42 PM
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Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury - tinyurl.com/zah9ydpz

#SpinalCordInjury(#SCI) #Neuroprotection #Cannabinoids #CannabisTherapy #NeuroScience #FunctionalRecovery #CBDTHCExtract #SCIRecovery
Cannabidiol/tetrahydrocannabinol-enrich extract decreases neuroinfalmmation and improves locomotor outcome following spinal cord injury Neuroinflammation is one of the main players in lesion expansion and locomotor deficits after spinal cord injury (SCI), thus treatments to control the inflammatory process emerge as novel therapeutic strategies. In this context, the anti-inflammatory effects of tetrahydrocannabinol (THC) and cannabidiol (CBD), the main phytocannabinoids of Cannabis sativa, are increasingly recognized. The aim of this work was to investigate the effects of a standardized Cannabis sativa extract (CSE), which is mainly composed by THC/CBD in equimolar concentration, on neuroinflammation, secondary damage and locomotor outcome after SCI in rats. After acute SCI, CSE therapy increased the number of non-inflammatory (arginase-1 positive) microglial cells in the epicenter of the lesion and decreased the number of pro-inflammatory ones (arginase-1 negative) in the epicenter and in the rostral and caudal regions of the lesion. CSE also reduced the number of reactive astrocytes in the grey matter of the rostral and caudal regions. These results are consistent with the downregulation of mRNAs of inflammatory mediators (IL-1β, TNFα, IL-6, C3) and the upregulation of anti-inflammatory markers (ARG-1, MRC). In the chronic phase, CSE treatment prevented cyst expansion and also increased the volume of spared grey and white matter. Regarding locomotor outcome, CSE-treated rats showed better locomotor scores (open field test), higher latency to fall (Rotarod test) and lower number of hindlimb foot misplacements (horizontal ladder walking test) than untreated injured rats. These results suggest that this standardized CSE offers a promising perspective for reducing acute neuroinflammation and promoting functional recovery after SCI.
March 31, 2025 at 6:56 PM
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Pilot Study on the Effect of Cannabidiol-Coated Fabric for Pillow Covers Improves the Sleep Quality of Shift Nurses
- tinyurl.com/2tue247e

After 3 weeks using CBD pillow covers, participants experienced improved sleep quality, increased light and deep sleep, and a significant reduction in anxiety
Pilot Study on the Effect of Cannabidiol-Coated Fabric for Pillow Covers Improves the Sleep Quality of Shift Nurses "Of the 55 participants, 10 were men (18.2%) and 45 were women (81.8%). At baseline, all participants exhibited poor sleep quality (PSQI ≥ 5). However, after three weeks of using CBD-coated pillow covers, subjective sleep quality significantly improved, with 7.3% of participants achieving PSQI scores <5. Additionally, slight changes in sleep patterns were observed, with increases in both light sleep and deep sleep durations. Light sleep duration increased from a baseline of 196.21 ± 65.28 to 206.57 ± 59.15 min two weeks after intervention (p = 0.337). Similarly, deep sleep duration showed a modest increase from 61.97 ± 21.01 min to 64.35 ± 22.19 min (p = 0.288). Furthermore, a significant reduction in anxiety levels was reported (p < 0.005)." "Using a CBD-coated pillow cover was found to enhance sleep duration in healthy individuals experiencing poor sleep. Consequently, for adults struggling with sleep difficulties, incorporating a CBD-coated pillow cover may serve as an effective aid in improving sleep quality." - https://freedomwares.ca/cbd-coated-fabric-for-pillow-covers-improves-shift-nurses-sleep/?fbclid=IwY2xjawJT2WNleHRuA2FlbQIxMAABHZyECYnnWdH6BsKQgCDvCVK7LG1AQe2jLCFOPoJU-qimtLQLhBe2zTkgHw_aem_ooKZGw42DB-C7NYv6ZSXkA
March 28, 2025 at 7:36 PM
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Antimicrobial Effects of CBD-infused Lozenges against Streptococcus mutans in Oral Health

This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science.
- tinyurl.com/4wchdt2s

#CBD #DentalCare #StreptococcusMutans #Antimicrobial
Antimicrobial Effects of Cannabidiol (CBD)-infused Lozenges against Streptococcus mutans in Oral Health A recent clinical trial has unveiled the potential of CBD-infused lozenges in combating harmful bacteria linked to tooth decay. Researchers explored the effects of CBD on Streptococcus mutans, a key player in cavity formation. Over 15 days, participants in the experimental group consumed one 300 mg CBD lozenge daily, allowing it to dissolve for gradual absorption. The results? A significant reduction in bacterial levels compared to the control group. This promising finding highlights CBD’s antimicrobial properties and its potential role in improving oral health. This study opens doors to innovative CBD-based therapies for dental care, an exciting step forward in oral hygiene science. - https://freedomwares.ca/antimicrobial-properties-of-cbd-lozenges/?fbclid=IwY2xjawJSyfFleHRuA2FlbQIxMAABHfxtrmxTwSO_cXVYvS3ONw_tdSjCsDgZKRO327_ycfYnC53piuTFaTqt-w_aem_ZDzZhvjACXDxAzYc32JGig #Cannabidiol(#CBD) #OralHealth #DentalCare #StreptococcusMutans #Antimicrobial #CBDLozenges #DentalResearch #HealthyMouth #CBDHealth
March 28, 2025 at 12:21 AM
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Development and Characterization of Cannabidiol Gummy Using 3D Printing

"Overall, 3D printing enables customizable CBD gummies with optimized release and offer a personalized and patient-friendly alternative to traditional oral forms for geriatric care."
- shorturl.at/DFqt2
Development and Characterization of Cannabidiol Gummy Using 3D Printing Revolutionizing Geriatric Care with 3D-Printed CBD Gummies These customizable CBD gummies, crafted using cutting-edge 3D printing technology, deliver precision dosing, improved elasticity, and optimized release. Compared to traditional gummies, they’re designed to be gentler, effective, and more patient-friendly; perfect for addressing the unique needs of older adults with conditions like oropharyngeal dysphagia. Could this be the next big thing in personalized medicine? 🤔 #GeriatricCare #Dysphagia #CannabidiolGummy #Cannabidiol(#CBD)
March 27, 2025 at 8:12 PM
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Cannabis-derived products are growing globally in human and veterinary medicine for conditions like pain, epilepsy, and sleep disorders. This study supports their positive use in animals, including dogs, cats, and horses, with potential benefits for humans.

Read more: tinyurl.com/yu9dus4h
Editorial: Use of cannabis derivatives in veterinary medicine Meme saying: "A growing body of evidence highlights the potential of cannabinoids as versatile therapeutic agents in veterinary medicine." "In human medicine, the use of cannabis-derived products is increasing globally for a variety of indications, such as post-injury and back pain, chronic and neuropathic pain, sleeping disorders, multiple sclerosis, epilepsy and others (Klatzkow et al.). Veterinary medicine is dovetailing this trend with growing interest from clients and veterinarians for treating medical conditions in animals with these molecules." This study supports the positive use of cannabis derivatives in veterinary medicine across multiple species, including dogs, cats, horses, and potentially even humans. Here are the key ways it helps: - Pain Management: Cannabis derivatives like CBD show therapeutic potential in managing pain, including conditions like osteoarthritis. - Epilepsy Treatment: Cannabinoids, particularly CBD, are studied for their efficacy in treating epilepsy in animals. - Improved Bioavailability: Studies on different CBD formulations in dogs and cats suggest that specific preparations lead to better absorption and higher plasma concentrations. - Long-Term Benefits: In horses, long-acting CBD formulations are shown to offer prolonged therapeutic effects, which is beneficial for consistent treatment. - Species-Specific Efficacy: Research highlights that different species (e.g., dogs vs. cats) respond differently to cannabis products, emphasizing the need for tailored treatments. These findings point to a growing interest and potential in using cannabis medicine across various species for treating chronic pain, epilepsy, and other conditions, although more research is needed for conclusive evidence.
March 26, 2025 at 8:21 PM
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Study finds that adding Cannabis sativa residues to broiler diets enhances meat flavor and nutrition without affecting growth. Higher CR levels increased amino acids and moisture while reducing fat. A promising natural feed additive! - freedomwares.ca/meat-quality...

#Poultry #SustainableFood
Broiler chickens fed with Cannabis sativa residues show improved meat quality and nutrition without affecting growth. A natural feed additive with potential benefits for poultry farming.
March 18, 2025 at 2:23 AM
freedomwares.bsky.social
A systematic study of molecular targets of cannabidiol in Alzheimer’s disease - tinyurl.com/42w2kkck

#CBD & #Alzheimer’s: Alzheimer’s is a chronic, incurable disease linked to amyloid-β buildup. Research suggests CBD, a non-psychoactive cannabis compound, may offer #neuroprotective benefits.
A systematic study of molecular targets of cannabidiol in Alzheimer’s disease Background: Alzheimer’s disease (AD) is a prevalent, incurable, and chronic neurodegenerative condition characterized by the accumulation of amyloid-β protein (Aβ), disrupting various bodily systems. Despite the lack of a cure, phenolic compounds like cannabidiol (CBD), a non-psychoactive component of cannabis, have emerged as potential therapeutic agents for AD. Conclusions: In summary, the study indicates that CBD and its analogs reduce the production of Aβ42. Overall, these findings support the potential of CBD in alleviating the underlying pathology and symptoms associated with AD, underscoring the crucial need for further rigorous scientific investigation to elucidate the therapeutic applications and mechanisms of CBD in AD.
March 17, 2025 at 2:26 AM
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#Motherhood and medicinal #cannabis

"Mothers reported medicinal cannabis as an important facilitator of their ability to positively parent their children, enabling them to manage their own health needs (i.e., #anxiety, #endometriosis and #arthritis)."

Read more: tinyurl.com/559s7zxa
#Motherhood and medicinal #cannabis "Mothers reported medicinal cannabis (MC) as an important facilitator of their ability to positively parent their children, enabling them to manage their own health needs (i.e., anxiety, endometriosis and arthritis). High costs of legal products hindered access to MC. Participants expressed unique risks that mothers face accessing the unregulated market for MC like being deemed a ‘bad mother’ and losing custody of children. Stigma was countered with narratives of empowerment through proactive MC conversations with children and agency by self-medicating with MC despite the judgement they may face for being a parent that uses cannabis." "Mothers felt managing their health with MC allowed them to be more present parents and better tolerate the stressors of motherhood. In-depth exploration of discussing MC with children and anticipating these conversations was a novel finding. Most mothers tried to destigmatise MC in conversations by classifying it in the same category as other medications and discussing its therapeutic benefits. Few were cautious about having these conversations too early."
February 20, 2025 at 2:43 AM
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Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications - tinyurl.com/4z4pzv7v

#AmyotrophicLateralSclerosis ( #ALS )
#EndocannabinoidSystem ( #ECS )
#NeuronalCellSurvival
#Cannabinoids
#QualityOfLife ( #QoL )
Amyotrophic Lateral Sclerosis, the Endocannabinoid System, and Exogenous Cannabinoids: Current State and Clinical Implications Online ahead of print. "A unifying mechanistic cause for amyotrophic lateral sclerosis (ALS) remains uncertain. Multiple pathophysiological processes appear to occur simultaneously. Cannabinoids, including delta-9-tetrahydrocannabinol (THC), cannabidiol (CBD), cannabigerol (CBG), and others found in cannabis, and cannabis extracts (CEs), appear to have activity in these pathogenic pathways, which have led to increasing interest in cannabinoids as therapeutic agents for ALS. The use of cannabinoids as a treatment strategy is substantiated by preclinical evidence suggesting a role for the endocannabinoid system (ECS) in ALS and other neurodegenerative disorders." "Preclinical data indicate that cannabis and CEs have powerful antioxidative, anti-inflammatory, and neuroprotective effects in the SOD1G93A mouse model of ALS. The use of CEs in SOD1G93A murine models has been shown to prolong neuronal cell survival, which leads to delayed onset of the disease state, and slows progression of the disease." "Although research in humans remains limited, a few studies suggest that cannabis and CBD, in humans, provide benefits for both motor symptoms, including rigidity, cramps, and fasciculations, and non-motor symptoms including sleep quality, pain, emotional state, quality of life, and depression." #AmyotrophicLateralSclerosis ( #ALS ) #EndocannabinoidSystem ( #ECS ) #ExogenousCannabinoids #MotorNeuronDisease #Neuroinflammation #Neuromuscular #Cannabinoids #SleepQuality #Pain #EmotionalState #QualityOfLife ( #QoL ) #More
February 13, 2025 at 8:01 PM
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“Smoking weed it gets you over the hump”: Cannabis co-use as a facilitator of decreased opioid use among people who inject drugs in Los Angeles, California

"Cannabis provided rapid relief from opioid withdrawal reducing frequency of opioid use."

- tinyurl.com/y2nrtzk4
"Smoking weed it gets you over the hump”: Cannabis co-use as a facilitator of decreased opioid use among people who inject drugs in Los Angeles, California "Using cannabis to provide rapid and ongoing relief from opioid withdrawal symptoms led to less frequent opioid use" "In our study, participants reported that cannabis assisted in developing patterns of reduced opioid use by decreasing frequency of opioid administration and providing a buffer period to initiate MOUD. Participants reported using cannabis substitution or co-use to manage the pain from withdrawal symptoms, such as body aches and generalized discomfort, which led to decreased opioid injection frequency. Participants emphasized low-barrier access due to legalization and numerous dispensaries as a resource that facilitated co-using cannabis for reduced opioid use. These findings support the extant literature on cannabis and opioid co-use for pattern changes among vulnerable populations." "Our findings expand the literature on cannabis legalization and opioid co-use to emphasize the possible benefits of accessible cannabis distribution programs, especially for indigent and unstably housed PWID. In Vancouver, an exploration of PWID perspectives on the role of grassroots cannabis distribution programs showed that participants support the development of low barrier, community-based, and peer-led distribution programs (Valleriani et al., 2020). These programs are favored over programs embedded within medical systems due to less access-related barriers such as cost, physician support, and requirements for personal identification and credit cards (Valleriani et al., 2020). Similarly, other grassroots initiatives called cannabis social clubs developed to model “collective self-supply" have illustrated the need for and importance of peer-to-peer distribution programs." "Additional research from Vancouver, Canada reported a 16 % increase in cessation of opioid injection linked to daily cannabis use."
February 3, 2025 at 8:32 PM
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Mosquitoes are perilous as they transmit many pathogens, causing lethal diseases like malaria, West Nile virus, and heartworm. "This study suggests that hemp extracts and cannabidiol are potentially valuable sources for developing biopesticides to control mosquitoes."
Read more: tinyurl.com/3cuxzefn
Larvicidal Activity of Hemp Extracts and Cannabidiol against the Yellow Fever Mosquito Aedes aegypti "Mosquitoes are considered the most dangerous animals on Earth because they are vectors of numerous pathogens that cause deadly and debilitating diseases in humans and domestic animals, including malaria, West Nile virus, and heartworm. The yellow fever mosquito Aedes aegypti is a vector of several arboviruses of medical importance, including chikungunya, dengue, yellow fever, and Zika. To limit the transmission of mosquito-borne arboviruses, humans have relied heavily on insecticides to control the larval and/or adult life stages of mosquitoes. Synthetic insecticides, such as pyrethroids, are critical chemical tools used for control; however, the widespread use of insecticides with limited modes of action has led to resistance. Additionally, the overuse of these insecticides has led to detrimental impacts on both human and environmental health. Thus, the discovery of alternatives to synthetic pesticides, like biopesticides, is crucial to improving mosquito management...." "This study suggests that hemp extracts and cannabidiol are potentially valuable sources for developing biopesticides to control mosquitoes." "Altogether, our study provides additional evidence supporting the notion that hemp is a valuable potential resource for developing novel insecticides to control mosquitoes." The present study examined whether extracts of hemp leaves were toxic to Aedes aegypti larvae and determined which compound(s) were responsible for the toxicity. We found that larvae, from both insecticide-resistant and -susceptible strains were killed by hemp leaf extract within 48 h of exposure. Furthermore, we found that an abundant cannabinoid (cannabidiol) within the extract was the primary active compound. This study suggests that hemp extracts and cannabidiol are potentially valuable sources for developing biopesticides to control mosquitoes."
January 30, 2025 at 7:04 PM
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"Polyphenolic compounds, including cannabinoids, terpenoids, and flavonoids; both natural and synthetic, have emerging evidence of nutraceutical, cosmetic and pharmacological potential, including specific anti-cancer, anti-inflammatory, and palliative utility." tinyurl.com/45rbt9w2
Phytochemical Constituents and Derivatives of Cannabis sativa; Bridging the Gap in Melanoma Treatment "Polyphenolic compounds, including cannabinoids, terpenoids, and flavonoids; both natural and synthetic, have emerging evidence of nutraceutical, cosmetic and pharmacological potential, including specific anti-cancer, anti-inflammatory, and palliative utility. Cannabis sativa is a wellspring of medicinal compounds whose direct and adjunctive application may offer considerable relief for melanoma sufferers worldwide. This review aims to address the diverse applications of C. sativa‘s biocompounds in the scope of melanoma and suggest it as a strong candidate for ongoing pharmacological evaluation." #Melanoma #Cannabis #Cannabinoids #Terpenoids #Biocompounds #Flavonoids
January 27, 2025 at 8:30 AM
freedomwares.bsky.social
Cannabis oil in treating #Parkinson’s disease: improvement of motor and non-motor symptoms: a case report - freedomwares.ca/cannabis-oil...
"These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson’s disease."
Cannabis oil in treating Parkinson’s disease: improvement of motor and non-motor symptoms: a case report "We present the case of a 77-year-old man diagnosed 22 years ago with PD in an advanced stage, with significant bradykinesia, tremor, and rigidity along with the inability to maintain an upright position and walk, exacerbated by a femur fracture. He also had advanced dysphagia, resulting in a gastrostomy. Although lucid, he showed no interest in conversation and tended to become depressed and isolated. He used Prolopa® with no satisfactory therapeutic response. After starting treatment with Cannabis sativa oil, he is now able to walk around the house frequently and eat pasty food regularly without choking or broncho-aspiration episodes. There has also been a significant improvement in non-motor symptoms; he is more active, cheerful, communicative, and attentive to his surroundings." "These compelling results suggest that cannabis oil may offer a valuable and effective therapeutic option for individuals with Parkinson’s disease."
January 23, 2025 at 12:10 PM
freedomwares.bsky.social
The Impact of Longitudinal Substance Use Patterns on the Risk of Opioid Agonist Therapy Discontinuation: A Repeated Measures Latent Class Analysis

Read more: tinyurl.com/3djebppd

#HarmReduction #Substitution #CannabisSubstitution #OpioidCrisis #ReducingOverdose #CannabisSubstitutionProject
The Impact of Longitudinal Substance Use Patterns on the Risk of Opioid Agonist Therapy Discontinuation: A Repeated Measures Latent Class Analysis "Collectively, our finding may point to a possible harm reduction strategy by substituting unregulated opioids with cannabis among people receiving Opioid Agonist Therapy (OAT)." "Additionally, recent research conducted in Vancouver suggested that cannabis use may help mitigate some of the negative effects of sub-therapeutic methadone dosing and help improve treatment retention (Lake et al., 2023; Socías et al., 2018)." More info: https://tinyurl.com/3djebppd
January 9, 2025 at 11:21 PM
freedomwares.bsky.social
Efficacy and safety of medical #cannabinoids in #children with #CerebralPalsy: a systematic review

"One of the most important potential of cannabinoids are related to its potential to help children with cerebral palsy, a contributor of lifelong disability." - freedomwares.ca/efficacy-and...
Efficacy and safety of medical cannabinoids in children with cerebral palsy: a systematic review "One of the most important potential of cannabinoids are related to its potential to help children with cerebral palsy, a contributor of lifelong disability."
December 30, 2024 at 6:08 AM
freedomwares.bsky.social
Pain Management for Older Adults Across the Cognitive Trajectory - shorturl.at/W3vXe
Chronic pain is associated with different levels of cognitive decline across the cognitive trajectory. Medical cannabis and music therapy are the two emerging non-pharmacological treatment methods. Clinical studies with rigorous research design are needed to further investigate the effects of these two strategies on pain relief in older adults.
December 23, 2024 at 6:10 AM
freedomwares.bsky.social
Comparative Analysis of Polyphenolic Profile and Chemopreventive Potential of Hemp Sprouts, Leaves, and Flowers of the Sofia Variety - freedomwares.ca/comparative-...
"The hemp products studied, namely leaves, flowers, and sprouts, represent functional food candidates, which could be implemented in the future as elements of dietary support in the chemoprevention of different diseases." - https://freedomwares.ca/comparative-analysis-of-polyphenolic-profile-and-chemopreventive-potential-of-hemp-sprouts-leaves-and-flowers-of-the-sofia-variety/?fbclid=IwZXh0bgNhZW0CMTAAAR0TZVwED4-2GAAfmDSuKy8q0lwWCt5lRivDROnIPBBGe4uUzH2vR_QCqH8_aem_afvnP6eI6BUwZ9AvmPkRvQ
December 23, 2024 at 6:07 AM
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Use of Cannabis-Based Medical Products for Pediatric Health Conditions: A Systematic Review of the Recent Literature - tinyurl.com/mryfkt93
Use of Cannabis-Based Medical Products for Pediatric Health Conditions: A Systematic Review of the Recent Literature "In the pediatric population, emerging evidence, combined with existing literature, suggests medical cannabis may be beneficial for quality-of-life symptoms related to specific conditions, like cancer, autism spectrum disorder, treatment-resistant epilepsy, and Sturge-Weber syndrome."
December 22, 2024 at 6:49 AM
freedomwares.bsky.social
~ tinyurl.com/mtakscb8
"These results suggest that CBD usage in pregnancy with inflammation conditions may be an effective therapeutic option for preventing conditions that may cause neuroinflammation in the fetal brain and adversely affect neurogenesis."
December 22, 2024 at 6:45 AM
freedomwares.bsky.social
Cannabis sativa extracts inhibit LDL oxidation and the formation of foam cells in vitro, acting as potential multi-step inhibitors of atherosclerosis development ~ tinyurl.com/b27dv3wm

#AtheroscleroticDisease #Cannabis #AtherosclerosisTherapy #Phytocannabinoids #CannabisExtracts #NewVenues
"Atherosclerotic disease is the leading cause of death world-wide." "Phytocannabinoids interfere with the main events leading to the development of the atheromatous plaque, opening new venues on atherosclerosis therapy."
December 22, 2024 at 6:43 AM
freedomwares.bsky.social
Cannabinopathic Medicine by Lester Grinspoon M.D. - tinyurl.com/2wst5y72
Illustration of a stethoscope with a cannabis leaf and caduceus, featuring a quote about cannabis from Dr. Lester Grinspoon, with the hashtag #CannabinopathicMedicine. - https://tinyurl.com/2wst5y72
December 22, 2024 at 5:24 AM