Fantastic series on the genetics of ALS from @thelancetneuro.bsky.social. Understanding these genetic subtypes will help therapeutic development for ALS and FTD.
tinyurl.com/544kx3fu

We need biomarkers to detect TDP-43 loss-of-function in plasma! This will make earlier therapeutic interventions possible for many neurodegenerative diseases. Here's a funding opportunity from AMP ALS if you have a great idea:

fnih.org/wp-content/u...

Excellent summary of potential therapeutic development for frontotemporal dementia resulting from granulin mutations.
www.nature.com/articles/s41587-025-02562-7