Fernando Gomez-Herreros Lab
@fgh-lab.bsky.social
DNA Repair and Gene expression in human disease. Andalusian research lab. Find us at the Institute of Biomedicine of Sevilla https://grupo.us.es/gomezherreroslab/gomezherreroslab/Home.html
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
July 29, 2025 at 8:36 AM
👉EWS::FLI1 modulates R-loop metabolism via DHX9, driving increased vulnerability to TOP1-targeting agents.
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!
👉Targeting TOP1 in EWS cells destabilizes the genome and provokes strong replication stress and cell death in EwS cells and tumors
Grateful to all collaborators who made this work possible!