Fernando Rossine
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fernpizza.bsky.social
Fernando Rossine
@fernpizza.bsky.social
Professionally playing with plasmids!
Postdoctoral Research Fellow @ Harvard Medical School
Moreover, to isolate within-cell dynamics from between-cell dynamics we used Mother Machines, microfluidic devices that isolate single cell lineages (thanks Carlos!). Look at how each trench first becomes clonal and then dimers are split and plasmid competition begins (8/n)
February 21, 2025 at 9:17 PM
When we implemented this system on a quasi-neutral pair of plasmids we could see genetic drift occurring first at the within-cell scale (yellow cells give rise to red and blue cells), and then at the between-cell scale (blue and red sectors progressively coarsen) (7/n)
February 21, 2025 at 8:42 PM