Peptide drugs are a powerful modality in modern drug discovery. Synthetic methods that enable the late-stage diversification of native peptides through amino acid-specific modifications are thus in high demand. In this work, we demonstrate the epimerization-free, chemoselective late-stage diversification of tryptophan-containing native peptides through nitrogen atom insertion in solution. The direct application of this rapid and straightforward method to structurally complex peptide drugs underscores the broader potential of atom insertion reactions in drug discovery beyond small molecules.

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Ferry crew reflects on rescuing stranded canoeists | Kitsap Daily News

Ensenada-San Diego ferry service on hold until operators get federal, state approval

From Lake Erie to Beaver Island to Mackinac, this ferry has an amazing Great Lakes resume.