This work is the result of a collaboration between many wonderful people: @grantyang.bsky.social, Yve, Casper, Matty, Scott, myself, and Silvi from @harvardmed.bsky.social; Dan H from @stanfordpress.bsky.social; and, for the first time as a PI, the great Lauren Hagler from @tamu.bsky.social !!

4/4

Aside from the app itself, we found that DMS-MaPseq + SEISMICgraph can be used to in vitro validate multiple riboswitches at once using a library, and that many of those riboswitches stop functioning if pseudoU is used instead of regular U (an important finding for those working in RNA tx).

3/4

The platform offers a plethora of graphs (see pic), and supports data coming from ShapeMapper, RNA framework, and SEISMIC; it should make the life of anybody analyzing DMS/SHAPE-MaP a lot easier :)

2/4

That looks cool, how did you do it ?!?!

Everybody should

I would have to say circRNAs, never ending possibilities (since they have no ends)

MicroRNAs are just so much fun