Fer Cofas
@fcofas.bsky.social
Assistant professor at IPPT PAN and PomaLab researcher, specializing in molecular recognition using coarse-grained MD and GōMartini to study protein-protein nanomechanics.
Reposted by Fer Cofas
🚨 Preprint! Our work complements affinity studies for antibodies (Ab) design
🔹 Mechanostability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...
🔹 Mechanostability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...
A Comparative Nanomechanical Study of Antibody and Nanobody Binding to SARS-CoV-2 Variants
The receptor-binding domain of the SARS-CoV-2 spike protein is the principal target of neutralizing antibodies (Abs) and nanobodies (Nbs). Although their thermodynamic binding properties have been ext...
www.biorxiv.org
September 29, 2025 at 7:36 AM
🚨 Preprint! Our work complements affinity studies for antibodies (Ab) design
🔹 Mechanostability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...
🔹 Mechanostability as design criterion for Abs against viral escape.
🔹 Two-chain topology: H chain bears force, L chain reinforces via inter-chain contacts.
Great work by @fcofas.bsky.social www.biorxiv.org/cgi/content/...
Reposted by Fer Cofas
GoGoGoGoGoGoGoMartini3 now finally published !
www.nature.com/articles/s41...
www.nature.com/articles/s41...
GōMartini 3: From large conformational changes in proteins to environmental bias corrections - Nature Communications
This work presents GōMartini 3, an improved coarse-grained protein model combining physics- and structure-based approaches. It boosts computational efficiency and accuracy for structured soluble and m...
www.nature.com
April 30, 2025 at 5:51 PM
GoGoGoGoGoGoGoMartini3 now finally published !
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Fer Cofas
MartiniGlass: a Tool for Enabling Visualization of Coarse-Grained Martini Topologies | Journal of Chemical Information and Modeling pubs.acs.org/doi/10.1021/...
MartiniGlass: a Tool for Enabling Visualization of Coarse-Grained Martini Topologies
As molecular modeling gains ever more prominence in understanding cellular processes, high quality visualization of models and dynamics has never been more important. Naturally, much molecular visuali...
pubs.acs.org
March 26, 2025 at 7:33 PM
MartiniGlass: a Tool for Enabling Visualization of Coarse-Grained Martini Topologies | Journal of Chemical Information and Modeling pubs.acs.org/doi/10.1021/...
November 25, 2024 at 8:01 AM