Farid Alisafaei
@faridalisafaei.bsky.social
Assistant Professor of Mechanical Engineering @njit.bsky.social
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PI, MechanoBiology and BioMechanics (MBBM) Lab http://www.mbbm-lab.com
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Former NIH Postdoc @upenn.bsky.social
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PI, MechanoBiology and BioMechanics (MBBM) Lab http://www.mbbm-lab.com
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Former NIH Postdoc @upenn.bsky.social
Pinned
Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell–extracellular matrix mechanical feedback - Nature Materials
Extracellular anisotropic stresses trigger fibroblast transition into myofibroblasts by the mechanical self-reinforcement of cell–extracellular matrix interactions.
www.nature.com
1️⃣ For years, scientists have known that mechanical tension influences cell behavior. But in our recent study in Nature Materials @naturematerials.bsky.social we found that it is not just the amount of tension—it is the direction!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Grateful to see our recent work on the mechanics of fibroblast activation featured by NJIT.
news.njit.edu/unveiling-bi...
news.njit.edu/unveiling-bi...
Unveiling the Biomechanical Forces that Drive Scarring
news.njit.edu
May 8, 2025 at 11:59 PM
Grateful to see our recent work on the mechanics of fibroblast activation featured by NJIT.
news.njit.edu/unveiling-bi...
news.njit.edu/unveiling-bi...
1️⃣ For years, scientists have known that mechanical tension influences cell behavior. But in our recent study in Nature Materials @naturematerials.bsky.social we found that it is not just the amount of tension—it is the direction!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell–extracellular matrix mechanical feedback - Nature Materials
Extracellular anisotropic stresses trigger fibroblast transition into myofibroblasts by the mechanical self-reinforcement of cell–extracellular matrix interactions.
www.nature.com
March 25, 2025 at 6:52 PM
1️⃣ For years, scientists have known that mechanical tension influences cell behavior. But in our recent study in Nature Materials @naturematerials.bsky.social we found that it is not just the amount of tension—it is the direction!
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Farid Alisafaei
Excited to share our latest work through our collaboration with Guy Genin, led by @faridalisafaei.bsky.social !
source.washu.edu/2025/03/the-...
source.washu.edu/2025/03/the-...
The right moves to rein in fibrosis
Biomedical researchers at Washington University in St. Louis have decoded how mechanical forces drive cell behavior in fibrosis.
source.washu.edu
March 25, 2025 at 3:22 AM
Excited to share our latest work through our collaboration with Guy Genin, led by @faridalisafaei.bsky.social !
source.washu.edu/2025/03/the-...
source.washu.edu/2025/03/the-...
1️⃣ For a long time, we have known that mechanical stretching influences how cells behave. But in our new PNAS paper @pnas.org, we show that fibroblasts do not just respond to stretch—they remember it.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Cell–matrix feedback controls stretch-induced cellular memory and fibroblast activation | PNAS
Mechanical stretch can activate long-lived changes in fibroblasts, increasing their
contractility and initiating phenotypic transformations. This a...
www.pnas.org
March 22, 2025 at 2:12 AM
1️⃣ For a long time, we have known that mechanical stretching influences how cells behave. But in our new PNAS paper @pnas.org, we show that fibroblasts do not just respond to stretch—they remember it.
www.pnas.org/doi/abs/10.1...
www.pnas.org/doi/abs/10.1...
Reposted by Farid Alisafaei
Tension-Induced Stiffening of Cytoskeletal Components Regulates Cardiomyocyte Contractility https://www.biorxiv.org/content/10.1101/2025.02.28.640898v1
March 7, 2025 at 6:48 AM
Tension-Induced Stiffening of Cytoskeletal Components Regulates Cardiomyocyte Contractility https://www.biorxiv.org/content/10.1101/2025.02.28.640898v1
(1) How can we better predict how much a meshed skin graft expands? What if surgeons had a practical tool to minimize the harvested skin needed for wound coverage?
Our new work in Acta Biomaterialia tackles this challenge:
sciencedirect.com/science/arti...
Our new work in Acta Biomaterialia tackles this challenge:
sciencedirect.com/science/arti...
sciencedirect.com
December 3, 2024 at 1:58 PM
(1) How can we better predict how much a meshed skin graft expands? What if surgeons had a practical tool to minimize the harvested skin needed for wound coverage?
Our new work in Acta Biomaterialia tackles this challenge:
sciencedirect.com/science/arti...
Our new work in Acta Biomaterialia tackles this challenge:
sciencedirect.com/science/arti...