Amanda Klingler
fairlyscience.bsky.social
Amanda Klingler
@fairlyscience.bsky.social
Ms.Frizzel if she was written and illustrated by Tim Burton. Teaching biology, science writing, and how to be informed citizens
Pinned
Hey all! I'm a teaching professor of biology, science writing consultant, and academic disability advocate. I am here after deleting Twitter looking to rebuild a community. Elon musk once called me a woke meat computer, let's be friends.
Reposted by Amanda Klingler
I am so heartened to this seriously AWESOME #SaveNSF website go up today!!!!

Has a take action toolkit with:

1. Press outreach templates
2. Social media toolkit
3. Elected official outreach
4. Talking points

Check it out and share widely!!!! Likely more to come.

www.savensf.com
May 2, 2025 at 10:08 PM
Reposted by Amanda Klingler
A tricky thing about modern society is that no one has any idea when they don’t die.

Like, the number of lives saved by controlling air pollution in America is probably over 200,000 per year, but the number of people who think their life was saved by controlling air pollution is zero.
April 7, 2025 at 4:13 AM
Reposted by Amanda Klingler
I’m excited to share that my first scientific research article has been published: pubs.acs.org/doi/10.1021/...

If someone had told my younger self that I would one day contribute to math-heavy scientific research, I would have found it hard to believe!
Normalized and Directional Interplay Scoring for the Interrogation of Proteoform Data
Histone proteoforms, often presenting multiple co-occurring post-translational modifications (PTMs), are central to chromatin regulation and gene expression. A proteoform is a specific form of a protein that includes variations arising from genetic changes, alternative RNA splicing, proteolytic processing, and PTMs. Genome-indexed histone proteoforms define the histone code, influencing cellular phenotype by dictating DNA interacting partners. Understanding the dynamics of histone proteoforms is essential for elucidating chromatin-based regulatory mechanisms. Advances in middle-down and top-down proteomics enable accurate identification and quantitation of thousands of proteoforms in a single run. However, the resulting data complexity presents significant challenges for analysis and visualization. Here, we introduce two new computational methods to analyze the dynamics of histone PTMs and demonstrate their use in mouse organs during aging. The score that we term “normalized interplay” addresses limitations of the original crosstalk score “interplay” providing a more complete and accurate measure of PTM crosstalk. The second score, ΔI or “directional interplay” is an asymmetric measure quantifying the magnitude and directionality of crosstalk between PTMs. Applying our two-stage scoring approach to data from CrosstalkDB reveals the dynamics of histone H3 modifications during aging.
pubs.acs.org
March 11, 2025 at 8:42 PM
Reposted by Amanda Klingler
“It is so disrespectful for Zelenskyy to not wear a suit in the White House.”
February 28, 2025 at 11:08 PM
Reposted by Amanda Klingler
www.nytimes.com/2025/02/22/s...

Featuring a quote from yours truly! Thank you for the opportunity to chat about accessibility in STEM during these trying times! #DisabledInSTEM
Accessibility Is Taking a Hit Across the Sciences
Confusion has ensued about the future of programs and research supporting people with disabilities as a result of President Trump’s executive order.
www.nytimes.com
February 22, 2025 at 6:18 PM
Attention all educators, keep reading for resources I have put together in light of the incoming immigration enforcement and the repeal of the sensitive locations policy (which previously prohibited ICE agents from conducting these activities in schools, hospitals, and churches)
January 23, 2025 at 9:26 PM
Reposted by Amanda Klingler
Elon just did this…
January 20, 2025 at 8:02 PM
Hey all! I'm a teaching professor of biology, science writing consultant, and academic disability advocate. I am here after deleting Twitter looking to rebuild a community. Elon musk once called me a woke meat computer, let's be friends.
January 19, 2025 at 6:59 PM