Fabienne Benz
@fabbenz.bsky.social
Working on the spread of antibiotic-resistance plasmids and the role of plasmid-encoded CRISPR-Cas currently postdoc @institut pasteur previously phd @ ETH
… I had to read it immediately and it is great! Congrats for this important piece of work Laura and Alvaro!
May 15, 2025 at 9:24 AM
… I had to read it immediately and it is great! Congrats for this important piece of work Laura and Alvaro!
6/6
🙏 Huge thanks to co-authors
@beatrizbeamud.bsky.social
@raphael-microb.bsky.social
@amandinemaire.bsky.social
@adecrulle.bsky.social
XavierDuportet
@dbikard.bsky.social
🙏 Huge thanks to co-authors
@beatrizbeamud.bsky.social
@raphael-microb.bsky.social
@amandinemaire.bsky.social
@adecrulle.bsky.social
XavierDuportet
@dbikard.bsky.social
May 15, 2025 at 6:53 AM
6/6
🙏 Huge thanks to co-authors
@beatrizbeamud.bsky.social
@raphael-microb.bsky.social
@amandinemaire.bsky.social
@adecrulle.bsky.social
XavierDuportet
@dbikard.bsky.social
🙏 Huge thanks to co-authors
@beatrizbeamud.bsky.social
@raphael-microb.bsky.social
@amandinemaire.bsky.social
@adecrulle.bsky.social
XavierDuportet
@dbikard.bsky.social
5/6 – Clinical opportunities
👩⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!
👩⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!
May 15, 2025 at 6:53 AM
5/6 – Clinical opportunities
👩⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!
👩⚕️ First-in-human trials already show safety and efficacy—proof CRISPR therapeutics can work in humans!
4/6 – The big hurdles
🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them
🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them
May 15, 2025 at 6:53 AM
4/6 – The big hurdles
🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them
🛡️ Bacterial defences — restriction–modification systems, anti-CRISPRs and mutational escape — and how to bypass them
3/6 – In-situ delivery
🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!
🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!
May 15, 2025 at 6:53 AM
3/6 – In-situ delivery
🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!
🚚 Engineered phages, conjugative plasmids & more — pros, cons, host range, cargo size and manufacturability. No one-size-fits-all!
2/6 – CRISPR-Cas strategies
🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ
🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ
May 15, 2025 at 6:53 AM
2/6 – CRISPR-Cas strategies
🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ
🧰 Toolbox & design considerations to eliminate bacteria or their plasmids — and to engineer microbes in situ