. @GardnerPhD @NutritionMadeS3 @mario_kratz @KevinH_PhD @DrDavidKatz @NanciGuestRDPhD @NicholasDCarter @DBelardoMD @vanvlietphd @theproof @mackinprof @LSchwingshackl @julie_abayomi @JanetCade @AuneDagfinn @hall_wendy @WardyMw @Pete_Scarbs @TyRBeal

This is a 'negative' study that is adequately powered (cross-over, 3 arms, repeated postprandial measurements, n=29), so showing the absence of effect of protein.

Our results indicate that, contrary to some findings in younger adults, adding protein to a challenge meal does not mitigate postprandial endothelial dysfunction and inflammatory activation in the elderly.

...including brachial flow-mediated dilation (FMD), hand microvascular reactivity (Flowmetry Laser Doppler, FLD), and finger reactive hyperemia index (Peripheral Arterial Tonometry, RHI).

In this cross-over study with high-saturated fat high-sucrose meals, we utilized milk protein as a reference and a blend of plant proteins whose amino acid composition was based on hypotheses regarding endothelial health, as suggested by literature findings in younger adults.

The aging population, often exposed to cardiometabolic risk factors, forms a crucial demographic for understanding the effects of protein and amino acids. Interventional studies in older humans are important to characterizing the effects of meal protein on endothelial health.

Comments welcome if you have time.
@GardnerPhD
@NutritionMadeS3
@mario_kratz
@DrDavidKatz
@NanciGuestRDPhD
@NicholasDCarter
@vanvlietphd
@theproof
@mackinprof
@AndreaGlennR
@LSchwingshackl
@julie_abayomi
@JanetCade
@AuneDagfinn
@hall_wendy
@WardyMw
@Pete_Scarbs
@tybeal and all...

congrats to @EliePerraud.

In women, bioavailable iron, which was the most limiting nutrient for total red meat minimization, requires special attention, and was identified as the nutrient to be secured beforehand for maximal reduction of red meat.

In the research that we report here, we could show that, if this is the primary goal, red meat can be readily decreased in the first steps of the pathways.

We have recently developed an innovative graph-based analysis of diet trajectory, which offers a unique opportunity to identify the critical first small steps for best pathways within millions of modelled diets towards an objective ().

Furthermore, although healthy, nutrient-adequate diets with no meat have been identified, these diets are much departed from current diets and not readily attainable for most people who yet are willing to eat less meat, and specifically willing to do so as a primary goal.

In western countries, the high level of meat is widely criticized because of its environmental impact and it is also questioned with the rise of animal welfare concerns. It is increasingly popular to reduce meat consumption, and more and more people are going "flexitarian"