EvE Bio
@evebio.bsky.social
EvE Bio is a nonprofit biomed research institute in Durham NC. We're a Focused Research Org on a 5-year mission to create the discipline of "pharmome mapping." What that means: https://evebio.org. Watch here for job & data drop announcements
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪
July 22, 2025 at 4:01 PM
Each of our bimonthly HTS data releases reveals previously unknown drug/off-target interactions, but some, like this snippet from last week's Release 5, showing that capsaicin is a highly selective agonist for the orphan nuclear receptor, ESRRB, deserves special note. 🧵 1/4 🧪
🧪Excited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.
July 18, 2025 at 12:51 PM
🧪Excited to learn that EvE Bio's unique pharmome-mapping data has been adopted by yet another biomedical reasoning model, Stanford's Biomni (biomni.stanford.edu). Awareness of and appreciation for our efforts is really snowballing. We're grateful to be of service to the community.
🧪 New toy! It's a robotic -20C freezer that can store 17,000 sample tubes, and upon command can spit out a rack containing just the tubes you've requested, in whatever pattern you want them. Everything is barcoded so the right sample always ends up in the right place. Or that's what they tell me.
June 6, 2025 at 1:25 PM
🧪 New toy! It's a robotic -20C freezer that can store 17,000 sample tubes, and upon command can spit out a rack containing just the tubes you've requested, in whatever pattern you want them. Everything is barcoded so the right sample always ends up in the right place. Or that's what they tell me.
🧪 EvE Bio's biggest public data release (#4) yet!
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
May 19, 2025 at 3:01 PM
🧪 EvE Bio's biggest public data release (#4) yet!
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
1.4k Rx drugs screened for 24 new potential off-targets including adrenergic, apelin, muscarinic, dopamine, gastrin-releasing, orexin, 5-HT, neuromedin, opioid, prostaglandin, sphingosine, somatostatin & neuromedin receptors. evebio.org/data
Wake up, babe. EvE Bio's data release #4 just dropped.
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
🧪Browse or DL (for non-commercial use) at evebio.org/data
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
🧪Browse or DL (for non-commercial use) at evebio.org/data
May 18, 2025 at 7:02 PM
Wake up, babe. EvE Bio's data release #4 just dropped.
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
🧪Browse or DL (for non-commercial use) at evebio.org/data
1.4k Rx drugs, 85 targets & counting:
237,490 combinations screened (mode/target/compound)
8 median agonists per target (potency < 1 uM)
31 median antagonists per target (potency < 1uM)
🧪Browse or DL (for non-commercial use) at evebio.org/data
Our data release #3, now live at data.evebio.org, adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy! 🧪
April 1, 2025 at 7:52 PM
Our data release #3, now live at data.evebio.org, adds 7 new nuclear receptors + 14 new 7TMs to our ever-growing list of human gene products screened against 1.4K FDA-approved drugs to ID off-targets, train AIs, repurpose drugs, and more. Enjoy! 🧪
Apparently we need to add "You must be a human" to the job requirements.
February 13, 2025 at 3:41 PM
Apparently we need to add "You must be a human" to the job requirements.
Celebrating a year of amazing efforts: by the upcoming end of its first year, EvE Bio's assay development team will have produced a whopping 200 validated HTS- and profiling-grade target actvity assays for nuclear hormone receptors (biochemical assay) and 7TM receptors (cell-based assay). Wow 😍 🧪
November 29, 2024 at 4:41 PM
Celebrating a year of amazing efforts: by the upcoming end of its first year, EvE Bio's assay development team will have produced a whopping 200 validated HTS- and profiling-grade target actvity assays for nuclear hormone receptors (biochemical assay) and 7TM receptors (cell-based assay). Wow 😍 🧪
Accurately summarizing the research literature would be a killer app (for us, anyway) for these LLMs, for which we have yet to find a genuinely useful application. But after how many terawatts and hundreds of billions of dollars, they're just still not there. Some are worse than merely not there 3/3
November 23, 2024 at 9:36 PM
Accurately summarizing the research literature would be a killer app (for us, anyway) for these LLMs, for which we have yet to find a genuinely useful application. But after how many terawatts and hundreds of billions of dollars, they're just still not there. Some are worse than merely not there 3/3
We're honored to find EvE Bio's efforts cited alongside heavy hitters like Protein Data Bank and Align to Innovate in renaissancephilanthropy.org 's new playbook on philanthropic support for mid-scale science efforts in open datasets and benchmarks. Thank you!
November 20, 2024 at 11:44 PM
We're honored to find EvE Bio's efforts cited alongside heavy hitters like Protein Data Bank and Align to Innovate in renaissancephilanthropy.org 's new playbook on philanthropic support for mid-scale science efforts in open datasets and benchmarks. Thank you!
🧪 Back when we were collecting voice-of-customer for EvE Bio, some of the best advice we received was "just put all your data on the web & smart young people will instantly start analyzing the bejeebers out of it."
Just released our first dataset and bejeeber #1 has already dropped! (alas, on x)
Just released our first dataset and bejeeber #1 has already dropped! (alas, on x)
November 20, 2024 at 12:27 AM
🧪 Back when we were collecting voice-of-customer for EvE Bio, some of the best advice we received was "just put all your data on the web & smart young people will instantly start analyzing the bejeebers out of it."
Just released our first dataset and bejeeber #1 has already dropped! (alas, on x)
Just released our first dataset and bejeeber #1 has already dropped! (alas, on x)