Súper excited to present my PhD work and meeting the amazing community of the @iuis-online.bsky.social @iuisjuniorcomm.bsky.social. Greatfull of sharing @openboxscience.bsky.social Initiative with the community! Step by step we can make science accesible to everyone in the world!

Other groups have shown that a fraction of intratumoral Tregs are actually pTregs, derived from the conversion of Th1 cells into pTregs mediated by TGF-β. A lot of research needed to solve the contribution of TGFb on nTreg vs pTreg in tumor promotion. rupress.org/jem/article/...

Using an elegant approach, it was demonstrated that a big majority of intratumoral Treg nTreg instead of pTreg. This is critical, as we normally think that TGF-b coming from the TME is promoting local Treg differentiation!🧐

www.science.org/doi/10.1126/...

What if TCRs didn’t need to see peptides to bind MHC?
A newly identified human TCR docks sideways onto HLA-DQ2.5—like an antibody.
This could reshape how we think about antigen recognition 🧐🧐 @niclag.bsky.social @naturecomms.bsky.social

😱Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force.
"Finally, we uncover that enteric neuronal Piezo1 function is required for motility alterations in colitis and acts to prevent aberrant inflammation and tissue damage"
www.cell.com/cell/fulltex...

This is something to look at! How sympathetic nerves could modulate T cell development in the thymus? Thymic Innervation Impairment in Experimental Autoimmune Encephalomyelitis.
@InctNim
karger.com/nim/article/...

T cells that have not undergone MHC selection can bind soluble antigens, such as proteins or peptides, without the need for MHC presentation. 😱😱https://www.sciencedirect.com/science/article/pii/S1074761311005206

New Year, New You! Ready to crush your fitness resolutions? Dive into our next seminar and unlock the secrets of how Tregs impact your gym results!
Thu, Jan 25, 9 am PT/12 pm ET
@KentLangston @harvardmed @SciImmunology
us02web.zoom.us/meeting/regi...

Sensory neurons promote immune homeostasis in the lung
www.cell.com/cell/fulltex...
Sensory neurons promote immune homeostasis in the lung

One of the things I love about sicence is that always I am blown away. I want to highlight the recent Alfred singer work! Autoreactive T cells are not depleted in the thymus, instead they are evicted to the periphery and tolerance is induced in the periphery.

www.science.org/doi/10.1126/...