Esther van Kleef
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esthervk.bsky.social
Esther van Kleef
@esthervk.bsky.social
Infectious disease epidemiologists working on AMR, modelling and ID surveillance @WHO and UoOxford. Alone we move fast, together we move mountains
October 23, 2025 at 8:51 PM
We should find sustainable mechanisms for these infrastructures and collaborations to stay, which may include funding models that bring together public, non-profit, and private-sector partners.

More to read in the full text. Thanks to all collaborators and funders @ec.europa.eu
October 23, 2025 at 8:39 PM
@chpoletto.bsky.social @sdellicour.bsky.social @mariusgilbert.bsky.social @lauradidomenico.bsky.social @eonore.bsky.social Wim V. Bortel, Elena Arsevska, Vittoria Colizza, L. Busani, Shengjie Lai, P. Lemey, S. Merler, Z. Milosavljevic, A Rizzoli, D. Simic, Andy Tatem, M. Teisseire, William Wint
October 23, 2025 at 8:33 PM
Intending to move beyond our “prepare-for-the-previous-pandemic” bias, this work highlights, among other findings, how the collaborative platforms and research consortia that emerged during COVID-19 laid the groundwork for new data and modelling ecosystems.
October 23, 2025 at 8:33 PM
However, systematic, quantitative analyses remain rare; for COVID-19 but also for previous PH threats. These reflections are easy to set aside once urgency fades and fatigue sets in, especially in an academic world that rewards moving on quickly and governments driven by short political cycles.
October 23, 2025 at 8:33 PM
Our main aim with this publication was to help preserve a collective memory of how data were generated, shared, and interpreted through modelling during the COVID-19 pandemic. Many opinions and reflections have been written.
October 23, 2025 at 8:33 PM
This has been a huge undertaking and a great leap forward in reporting global AMR surveillance data. For the first time, country, and regional-level data are supported my Bayesian modelling that allow for better comparison of resistance rates between countries/ regions and trends over time @who.int
October 9, 2025 at 9:32 PM
Certainly! And sharing the knowledge here in England whenever I can now stroopwafels are almost as much an export product as Gouda cheese…
May 4, 2025 at 5:08 PM
The first preview was also presented at ESCMID global see tinyurl.com/4sh5v3hf. Combined these reports provide valuable new insights to enhance country-level use of GLASS data to help inform local, national, and regional AMR strategies World Health Organization #UNGA.
April 29, 2025 at 3:18 PM
The GLASS report on antimicrobial resistance (AMR) will be published separately later this year. The 2025 GLASS AMR report will expand on previous editions by presenting regional- CTA-level AMR estimates and trends across 93 pathogen-antibiotic combinations from CTAs enrolled by the end of 2024.
April 29, 2025 at 3:18 PM
Emphasising the relevance of such information is something I feel we should target, among others by working on direct ways (eg good dashboards) of feeding back national and local AMR/isolate data. Until then, we are limited to reporting AMR prevalence.
April 15, 2025 at 7:49 PM
On another note: WHO GLASS has moved to individual isolate reporting since 2023. This is great and will provide a first possibility to move beyond reporting prevalences only. But countries to date struggle even to report much needed denominators for incidence.
April 15, 2025 at 7:45 PM
In addition, national surveillance guidance is underway, aiming to inform national action, not global estimates as a stand alone. Discussion are ongoing. For an early version of the survey guidance, see here www.who.int/publications.... Of note: both ACORN I and II and these surveys are intensive.
GLASS method for estimating attributable mortality of antimicrobial resistant bloodstream infections
Global Antimicrobial Resistance Surveillance System (GLASS)
www.who.int
April 15, 2025 at 7:27 PM
Good news is that WHO and ACORN collaborators have been working on this in tandem, I.e currently piloted WHO surveys on estimating burden, incl. all indicators presented by ACORN are developed in close consultation with/borrowing from similar protocols for places where MML access is challenging
April 15, 2025 at 7:21 PM
Our findings can inform the design of pandemic intelligence systems now emerging across Europe and globally, and support efforts like the Lancet Commission on Strengthening the Use of Epidemiological Modelling—to guide future policy, methods, and communication. 4/5
March 28, 2025 at 9:13 AM