Congratulations, what a great success 🎉🎉 @hih-tuebingen.bsky.social #7TMRI #layer #career

Thanks a lot for featuring my group with the title story on our new paper on #layer specific #sensory #aging in #humans and #mice making the point that cortical layers do not age homogenously pubmed.ncbi.nlm.nih.gov/40790266/

Congratulations Peng, fantastic achievement! 🎉

6/6 Together we introduce a new layer model of sensory aging highlighting non-homogenous cortical aging at different layers This may help to better understand the complex changes in cortex architecture that characterize healthy vs pathological aging & associated impairments in everyday life

5/6 We replicate age- and layer-specific profiles detected in humans with #7T #MRI in aging mice & provide more details on the potential underlying neuronal mechanisms (MBP=myelin basic protein) Note: the older mice are at an age comparable to our older adults but the old mice are even older

4/6 Interesting is also to inspect the SI layer-specific qT1 (myelin) profile of n=1 person born without one arm ipsi versus contralateral to missing arm (data are in Supplemental Material)

3/6 The structurally more pronounced middle layer (including layer 4) also shows a larger sensory-driven functional peak in older adults This was evidenced in an independent cohort (blue=younger red=older)

2/6 First insight: Age-related cortical thinning in SI is not homogeneous across layers but driven by deep layer thinning The middle layer instead is even thicker in older adults

Two minutes that can change your life sounds interesting - are the slides somewhere to download?

Impressive work, congratulations!