Eugene Serebryany
@eserebry.bsky.social
Protein mis/folding & engineering, peptides, molecular ophthalmology, chembio | Asst. Prof. Stony Brook University
Proud to share our newest preprint. We introduced conformational constraints (disulfides) into alpha-synclein and measured effects on aggregation. There were surprises, including a possible new amyloid polymorph and a substoichiometric chaperone-like aggregation inhibitor.
doi.org/10.64898/202...
doi.org/10.64898/202...
Disulfide engineering reveals unexpected pro- and anti-aggregation conformers of human α-synuclein
Intrinsically disordered proteins can aggregate in many distinct conformations (polymorphs). Polymorphs are a striking example of fold-switching: one primary structure able to form distinct tertiary s...
doi.org
January 9, 2026 at 5:39 AM
Proud to share our newest preprint. We introduced conformational constraints (disulfides) into alpha-synclein and measured effects on aggregation. There were surprises, including a possible new amyloid polymorph and a substoichiometric chaperone-like aggregation inhibitor.
doi.org/10.64898/202...
doi.org/10.64898/202...
Proud to share a new manuscript from my group: www.biorxiv.org/content/10.6... We found an unexpected intramolecular conformational rearrangement that triggers aggregation of a lens crystallin. This could be a weak link that leads to age-onset cataract, and hence a potential target for preventing it
| bioRxiv
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
www.biorxiv.org
December 30, 2025 at 6:09 PM
Proud to share a new manuscript from my group: www.biorxiv.org/content/10.6... We found an unexpected intramolecular conformational rearrangement that triggers aggregation of a lens crystallin. This could be a weak link that leads to age-onset cataract, and hence a potential target for preventing it
The Laufer Center for Physical & Quantitative Biology is recruiting for an endowed professorship! It is a great community to be part of. Asst. or Assoc., or even Full Prof. candidates are welcome! apply.interfolio.com/173357
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September 17, 2025 at 5:28 PM
The Laufer Center for Physical & Quantitative Biology is recruiting for an endowed professorship! It is a great community to be part of. Asst. or Assoc., or even Full Prof. candidates are welcome! apply.interfolio.com/173357
Proud to share the first paper fully from the Serebryany Lab, now officially In Press! Here we report a simple but previously overlooked approach to biomanufacturing seamlessly cyclized peptides. Big congrats to my talented Ph.D. student, Ali Behboodian. authors.elsevier.com/a/1lmU%7E_1l...
authors.elsevier.com
September 15, 2025 at 1:17 AM
Proud to share the first paper fully from the Serebryany Lab, now officially In Press! Here we report a simple but previously overlooked approach to biomanufacturing seamlessly cyclized peptides. Big congrats to my talented Ph.D. student, Ali Behboodian. authors.elsevier.com/a/1lmU%7E_1l...