Erin Doherty
@erinedoherty.bsky.social
Postdoc @ Doudna Lab, UC Berkeley 🧬 | Chemical & Structural Biology | Immunity Mechanisms | CRISPR | RNA-Editing |
F32 NRSA | Berkeley Chancellor's Fellow
UC Davis Beal Lab Alum | Former CIRM, NIH F31 & NIH T32
F32 NRSA | Berkeley Chancellor's Fellow
UC Davis Beal Lab Alum | Former CIRM, NIH F31 & NIH T32
We determined that mCpol produced c-di-AMP and a crystal structure of mCpol bound to an ATP analog showed that regions homologous to regulatory features in Cas10 were replaced by highly stable structures, consistent with our observation that mCpol is a constitutively active cyclase.
March 31, 2025 at 4:29 PM
We determined that mCpol produced c-di-AMP and a crystal structure of mCpol bound to an ATP analog showed that regions homologous to regulatory features in Cas10 were replaced by highly stable structures, consistent with our observation that mCpol is a constitutively active cyclase.