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Reposted

Leopold Parts

@leopoldparts.bsky.social

We're delighted to share our work on scrambling the human genome using prime editing, repetitive elements, and recombinases in @science.org , led by @jonaskoeppel.bsky.social , @f-raphael.bsky.social , with @proftomellis.bsky.social and George Church.
www.science.org/doi/10.1126/...

Randomizing the human genome by engineering recombination between repeat elements

We lack tools to edit DNA sequences at scales necessary to study 99% of the human genome that is noncoding. To address this gap, we applied CRISPR prime editing to insert recombination handles into re...

www.science.org

January 31, 2025 at 1:49 PM

Reposted

Sudarshan Pinglay

@sudpinglay.bsky.social

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Multiplex generation and single-cell analysis of structural variants in mammalian genomes

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

www.science.org

January 31, 2025 at 7:41 PM

Reposted

Matthias Nau

@matthiasnau.bsky.social

Want to make beautiful scientific figures? Easy!

The NIH released a library of 2000+ free scientific illustrations called *BioArt*.

Check it out! bioart.niaid.nih.gov

#AcademicSky #PsychSciSky 🧠🟦 🧪

October 30, 2024 at 9:45 AM

Reposted

🦋 Gourdon Lab 🦠🔬

@delphe.bsky.social

Super cool for so many of us ➡️ The Human Tumor Atlas Network (HTAN) is constructing 3D atlases of the cellular, morphological, molecular, and spatial features of human #cancers (and their #microenvironments) over time 🧪

#mechanobiology #microscopy #physicsoflife

www.cancer.gov/about-nci/or...