happy to help if you have any question when trying it!

🔗 Find out more
📄 Preprint: doi.org/10.1101/2025...
💻 GitHub: github.com/earmingol/sc...
📚 Tutorials: sccellfie.readthedocs.io

🤝 Thanks to the Vento Lab and all collaborators!
We hope scCellFie supports your exploration of metabolism in health & disease 🧪
#Metabolism

🧱 In endometrial carcinoma, scCellFie revealed:
• Spatially organized metabolic activities
• Tumor-associated estrogen & kynurenine signaling
• Metabolic tasks linked to tumorigenesis potential
#CancerResearch #SpatialTranscriptomics #SpatialBiology

⚠️ In endometriosis, we found:
• Proinflammatory metabolism in macrophages
• Increased glycolysis & lipid metabolism in epithelial cells
• Shared metabolic shifts in eutopic & ectopic tissues
#Endometriosis #Inflammation

🚺 In the human endometrium, we captured metabolic rewiring across the menstrual cycle — including functions that help with tissue remodeling and managing oxidative stress.
#Endometrium #ReproductiveHealth

🌐 We built a metabolic atlas from ~30 million cells across human organs using @cziscience’s Human Cell Atlas.
Explore it online:
🗺️ www.sccellfie.org
#HumanCellAtlas #SingleCell

🔧 What is scCellFie?
A tool to infer interpretable metabolic insights from single-cell and spatial transcriptomics.
🧰 Key features:
• Metabolic markers
• Condition-specific changes
• Spatial & temporal patterns
• Metabolite-based cell communication